Dipharma S.p.a.

Chemo Iberica, S.a.

Dipharma Francis S.r.l.

Dinamite Dipharma S.p.a.

Secifarma S.p.a.

Domenico Magrone

Giuseppe Barreca

Walter Cabri

Gabriele Razzetti

Gianpiero Ventimiglia

Graziano Castaldi

Pietro Allegrini

Marcello Rasparini

Alberto Bologna

Luca Carcone

Mauro Ercoli

Erminio Oldani

Huang Liming

Roberto Angelini

Huan Liming

Fabio Massimo Bravin

It is described a process for the opening of lactone or lactam rings useful in the synthesis of pharmaceutically active compounds and the intermediates thereof, particularly Aliskiren. It has found that by selecting a type of solvent it is possible to obtain excellent yields and high optical and chemical purity of the isolated products.

Chemical process for opening ring compounds

Are disclosed new crystalline forms of asenapine maleate, useful in the production of pharmaceutical formulations for the treatment of diseases of the central nervous system, in particular schizophrenia; processes for the production of these new crystalline forms are also disclosed.

Polymorphic forms of asenapine maleate and processes for their preparation

Ziprasidone base or a pharmaceutically acceptable salt thereof free from colored impurities, in particular those giving the product a 'slightly pink to pink' coloration.

Ziprasidone free from colored impurities and a process for its preparation

Novel phenyltetrazole compounds useful as intermediates in the preparation of angiotensin II antagonists and the processes for the conversion thereof to biologically active molecules.

Phenyltetrazole compounds

A process for the preparation of 4-&lsqb;1-hydroxy-4-&lsqb;4-(hydroxydiphenylmethyl)-1-piperidinyl&rsqb;-butyl&rsqb;-&agr;,&agr;-dimethylbenzeneacetic acid (Fexofenadine) of formula

Process for the preparation of 4-&lsqb;1-hydroxy -4-&lsqb;4-(hydroxydiphenylmethly)-1-piperidinyl&rsqb;-butyl&rsqb;-&agr;, &agr;-dimethylbenzeneacetic acid

A process for the purification of (RR,SS)-2-(dimethylamino)methyl-1-(3-methoxyphenyl)cyclohexanol, which comprises the selective precipitation of (RR,SS)-2-(dimethylamino)methyl-1-(3-methoxyphenyl)cyclohexanol in the presence of (RS,SR)-2-(dimethylamino)methyl-1-(3-methoxyphenyl)cyclohexanol from a solvent consisting of water and a water-miscible organic solvent.

Process for the purification of (RR,SS)-2-(dimethylamino) methyl-1-(3-methoxyphenyl)-cyclohexanol from (RS,SR)-2-(dimethylamino)methyl-1-(3-methoxyphenyl) cyclohexanol

An improved process for the preparation of Nabumetone, which comprises the following steps:

Process for the preparation of 4-(6'-methoxy-2'-naphthyl) butan-2-one

Growing community of inventors

Milan, Italy

Domenico Magrone