Glaxo Group Limited

Glaxosmithkline LLC

Domenica Antonia Pizzi

Colin Philip Leslie

Jessica Tibasco

Alessandro Falchi

Matteo Biagetti

Giancarlo Merlo

Marilisa Rinaldi

Luigi Piero Stasi

Simon Edward Ward

Barbara Bertani

Markus Bergauer

Steven Mark Bromidge

Antonio Kuok Keong Vong

Giovanni Gaviraghi

Daniele Andreotti

Luca Tarsi

Giovanna Tedesco

Tino Rossi

Stefano Biondi

Aldo Feriani

Emiliangelo Ratti

Gabriella Finizia

Disclosed are methods for the preparation of compounds of formula (I): wherein R, m, X, R, n, W, p, Y, Z, R, R, Rand q have the meanings as defined in the description.

Quinoline and quinazoline derivatives having affinity for 5HT1-type receptors

Disclosed are methods for use of compounds of formula (I) in combination with other active substances in the treatment of CNS disorders such as depression or anxiety. wherein R, m, X, R, n, W, p, Y, Z, R, R, Rand q have the meanings as defined in the description.

Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided: wherein R, m, X, R, n, W, p, Y, Z, R, R, Rand q have the meanings as defined in the description. Methods of preparation and uses thereof in therapy, particularly for CNS disorders such as depression or anxiety, are also disclosed.

A compound of formula (I), salts and metabolically labile esters thereof, wherein R represents optionally substituted aryl or heteroaryl group; A represents a propylene chain or A is a chain of members one of which is selected from an oxygen or sulphur atom or the group NH or a substituted derivative thereof and the other two members are methylene groups, having antibacterial activity, processes for their preparation and to their use in medicine.

Tricyclic carbapenem compounds

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Verona, Italy

Domenica Antonia Pizzi