Pharma Mar, S.a.

Instituto Biomar, S.a.

Universidad Complutense De Madrid

Other

Universidad De Salamanca

Pharma-mar, S.a.- Pharmar

University of Illinois

Universidad De Cádiz

Universidad De Santiago De Compostela

Dolores Garcia Gravalos

Jose Luis Fernandez Puentes

Tatsuo Higa

Glynn Thomas Faircloth

Francisco Romero Millan

Paul J Scheuer

Mark T Hamann

Julia Perez Baz

Gabriel Tojo Suarez

Jose Delamano Garcia

Teresa Garcia De Quesada

Kenneth L Rinehart

John W Blunt

Robert A Warwick

Francisco Romero

Fernando Espliego

Maria Angeles Castro

Jose Maria Del Corral

Maria Luisa Lopez

Arturo San Feliciano

Marina Gordaliza

Yoel Kashman

Nancy L Fregeau Gallagher

Ana Rodriguez Quesada

Benedikt Sas

Carmen Avendano Lopez

Koen Alexander

Jesus Avila

Murray H Munro

Junichi Tanaka

Librada Maria Cañedo

Julia Perez-Baz

Carmen Avendano

Cristina Acebal Sarabia

Librada Canedo Hernandez

Jes&uacute;s Angel De La Fuente

Alice E D Scheuer

Eva Zubia

Tesfamariam Yosief

Amira Rudi

Maurice Aknin

Maria J Ortega

Julia Perez

Ganit Koren-Goldshlager

Javier Salva

Librada Maria Ca&ntilde;edo

Bruce Frederick Bowden

G Bernardinelli

C W Jefford

Jun-Ichi Tanaka

Jose Carlos Menendez Ramos

Khanit Suwanoborirux

Santiago Naranjo Lozano

Maria Del Mar Blanco Castro

Murray Herbert Gibson Munro

Jos&eacute; Luis Fernandez Puentes

Toshio Ichiba

Sylvia Urban

Jos&eacute; Mar&iacute;a Perez

Jos&eacute; Carlos Menendez

Carmen Lopez Goti

Mar&iacute;a Jes&uacute;s Martin

Jesus Fernandez Almeida

Rosario Duran

Marc S Litaudon

Maria Del Mar Blanco

Robin J Lake

KalahideKahalalideF, of formula I below, may be isolated from a sacoglossan. The compound may be used in the manufacture of pharmaceutical compositions or in the treatment of tumors or viral conditions

Kahalalide F and compositions and uses thereof

Naturally occurring stolonoxide compounds, and derivatives thereof, have antitumor activity. Typical compounds are of the formula (I) or a derivative thereof 

Stolonoxides

The invention provides a compound of formula (I). This invention relates to heterocyclic compounds. It further relates to methods for their preparation, compositions cotaining them and their use as a medicament, particularly as a medicament for the treatment and prophylaxis of cancer. 

Antitumoral carbazoles

Investigation of the activity of extracts of the clamhas led to antitumor long-chain, straight-chain alkane or alkene compounds which have a 2-amino group and a 3-hydroxy group. The present invention is directed to compositions and methods comprising an isolated and purified long-chain, straight-chain 2-amino-3-hydroxyalkane, or prodrug thereof, and a pharmaceutically acceptable carrier, wherein the carbon chain in the long-chain, straight-chain 2-amino-3-hydroxyalkane is C&#x2013;C.

Compositions and methods comprising long-chain, straight-chain 2-amino-3-hydroxyalkanes

Compounds of formula (I) wherein Ris selected from H, C(&#x2550;O)R', P(&#x2550;O)R&#x2032;R&#x2033;, S(&#x2550;O)R&#x2032;R&#x2033;, substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, substituted or unsubstituted C-Calkynyl, or substituted or unsubstituted aryl; or Rtogether with Rforms a saturated or unsaturated heterocyclic ring; Rand Rare each, independently, selected from H, C(&#x2550;O)R&#x2032;, P(&#x2550;O)R&#x2032;R&#x2033;, S(&#x2550;O)R&#x2032;R&#x2033;, substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, substituted or unsubstituted C-Calkynyl, or substituted or unsubstituted aryl; or one of Ror Rtogether with Rforms a saturated or unsaturated heterocyclic ring; or Rand Rtogether form a saturated or unsaturated heterocyclic ring; Ris selected from H, C(&#x2550;O)R&#x2032;, P(&#x2550;O)R&#x2032;R&#x2033;, S(&#x2550;O)R&#x2032;R&#x2033;, substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, substituted or unsubstituted C-C, alkynyl, or substituted or unsubstituted aryl, wherein R&#x2032; is selected from the group consisting of H, OH, NO, NH, SH, CN, halogen, C(&#x2550;O)H, C(&#x2550;O)CH, COH, COCH, substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, substituted or unsubstituted C-Calkynyl, substituted and unsubstituted aryl; R&#x2033; is selected from the group consisting of H, OH, NO, NH, SH, CN, halogen, &#x2550;O, C(&#x2550;O)H, C(&#x2550;O)CH, COH, COCH, substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, substituted or unsubstituted C-Calkynyl, substituted and unsubstituted aryl; wherein X, XXon formula I are independently placed in any particular position of the chain and independently selected from H, OH, OR&#x2032;, SH, SR&#x2032;, SOR&#x2032;, SOR&#x2032;, NO, NH, NHR&#x2032;, N(R&#x2032;), NHC(O)R&#x2032;, CN, halogen, &#x2550;O, C(&#x2550;O)H, C(&#x2550;O)CH, COH, COCH, substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, substituted or unsubstituted C-Calkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaromatic, wherein substituent groups defined by R&#x2032; are each independently selected from the group consisting of H, OH, OR&#x2032;, SH, SR&#x2032;, SOR&#x2032;, SOR&#x2032;, NO, NH, NHR&#x2032;, N(R&#x2032;), NHC(O)R&#x2032;, CN, halogen, &#x2550;O, C(&#x2550;O)H, C(&#x2550;O)CH, COH, COCH, substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, substituted or unsubstituted C-Calkynyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaromatic; wherein x is 6 to 20; and wherein the dotted lined is one or several optional double bonds placed in any particular position of the side chain; or pharmaceutically acceptable salts thereof are useful as antitumor compounds and include compound IK-8-73-4 of structure (a) which was isolated from a spongesp.

Oxy-and amino-substituted tetrahydrofuryl derivatives with antitumour activity

The invention provides compounds of formula (1) wherein Ris a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or an alkoxy group having 1 to 6 carbon atoms; and Ris a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or an alkoxy group having 1 to 6 carbon atoms; and pharmaceutically acceptable salts thereof. The invention also relates to a process for obtaining the compounds, compositions containing them and their therapeutic use. The compounds display excellent activity against mammalian cancer cell lines.

Indolocarbazole alkaloids from a marine actinomycete

A novel class of antitumour compounds has been recognised based on the isolation from a new marine microbe, strain PO13-046, belonging to the genus sp.), of a compound designated IB-00208. The class of the formulae (I) or (II) where R can be hydrogen, acyl, alkyl, alkenyl, aryl, benzyl, alkali metal, and/or sugar, and R and R can be hydrogen, alkyl, or together R and R form an unsaturated bond. Such compounds demonstrate an interesting activity several cancel cell lines and against Gram-positive bacteria.

Polycylic xanthones and their use

Investigation of the activity of extracts of the clam has led to antitumour long-chain, straight-chain alkane or alkene compounds which have a 2-amino group and a 3-hydroxy group.

Spisulosine compounds

Cytotoxic compounds: derivatives of the pyrido&lsqb;2,3,4-kl&rsqb;acridine ring system

Compounds having formula (I) wherein R , R , R and R are independently selected from the group consisting of hydrogen, lower alkyl, halogen, amine, mono(lower)alkylamine, di(lower)alkylamine, phenyl, or substituted phenyl possess antitumor activity and are new with the exception of the compound in which R , R , R , R are all hydrogen and the compound in which R and R are hydrogen, R is chlorine, and R is a 2-nitrophenyl group.

Antitumour 1,5-diazaanthraquinones

Disclosed are the compounds Asamarine A and B, novel cytotoxic diterpene-alkaloids, that have been isolated from the sponge Raspailia sp. The structure of these compounds have been established on the basis of NMR data and confirmed by X-ray analysis. Also disclosed are compounds (I) and (II), wherein wherein R represents hydrogen or lower alkyl or lower alkanoyl; R represents hydrogen or lower alkyl; R is either an alkyl or a cycloalkyl group containing one or more isoprene units, or a monoterpene or a sesquiterpene or a sesquiterpene or a diterpene group; R or R represent hydrogen or lower alkyl; R represents lower alkyl; and X represents F or Cl or Br or I.

Cytotoxic alkaloid derivatives including Asmarine A and B isolated from a sponge

Cytotoxic tris(oxazole)-containing macrolides

Cytotoxic pyridoacridine alkaloids

Kalahide F, of formula I below, may be isolated from a sacoglossan. The compound may be used in the manufacture of pharmaceutical compositions or in the treatment of tumors or viral conditions.

Cytotoxic and antiviral compound

The present invention is directed to a novel depsipeptide has been isolated from a new marine strain L-13-ACM2-092 belonging to the family Micromonosporaceae. Its production by aerobic fermentation under controlled conditions of the strain, and the isolation and purification of PM-93135 are described herein. The compound and the fermentation broth demonstrate significant activity against several cancer cell lines. The compound also shows activity against several gram positive bacteria.

Method of treating tumors with thiodepsipeptide isolated from a marine actinomycete

Growing community of inventors

Madrid, Spain

Dolores Garcia Gravalos