Korea Ocean Research and Development Institute

Korea Ocean Research Institute

Doc Kyu Kim

Joung Han Yim

Il Chan Kim

Se Jong Han

Sung Jin Kim

Tai Kyoung Kim

Ha Ju Park

Hyoung Seok Lee

Pil-Sung Kang

Heeyong Park

Hyun Cheol Oh

Jung Eun Kim

Dong-Gyu Jo

Mi Ra Park

Pyung Cheon Lee

Bhattarai Hari Datta

Cheolsoon Lee

Keun-Sik Kim

Yu-Kyung Park

Sung Gu Lee

Hong Kum Lee

Hari Datta Bhattarai

Yoo Kyung Lee

Soon Gyu Hong

Paudel Babita

Babita Paudel-Bhattarai

Suhkneung Pyo

Jong Han Yim

Ii Chan Kim

The present invention relates to the novel use (anti-inflammatory activity) of Ramalin isolated from the Antarctic lichen, and more specifically to a pharmaceutical composition containing Ramalin as an active ingredient. Ramalin of the invention is a compound derived from natural material, has no toxicity or side effects, and inhibits the expression of inducible nitric oxide synthase (iNOS) in the transcription stage to significantly inhibit the production of nitric oxide (NO) that is a key mediator of inflammatory responses. In addition, it inhibits the activation of the inflammatory mediator NF-&#x3ba;B, inhibits p38 MAPK, ERK1/2 and JNK signaling pathways, and inhibits the expression of the LPS receptor TLR4, suggesting that Ramalin has an excellent anti-inflammatory effect. Thus, the composition containing Ramalin can be effectively used to fundamentally treat or prevent inflammatory diseases or immune diseases and to relieve or alleviate the symptoms of the diseases.

Pharmaceutical composition for the prevention or treatment of inflammatory diseases or immune diseases containing ramalin

The present invention relates to pharmaceutical and food compositions for preventing or treating diabetes or obesity, and more particularly to pharmaceutical compositions and functional foods for preventing or treating diabetes or obesity, which contain, as an active ingredient, a novel compound synthesized from a compound separated from an extract of the. The novel compounds of the invention have very excellent PTP-1b (protein tyrosine phosphatase-1b) inhibitory activities, act selectively only on PTP-1b among protein tyrosine phosphatases, and are substantial PTP-1b inhibitors which are effective in preventing or treating diabetes or obesity.

Pharmaceutical and food compositions for preventing or treating diabetes or obesity

The present invention relates to a novel compound having excellent antioxidant activity, isolated from, and more particularly to a novel compound, RAMALIN&#x2122;, having excellent antioxidant activity, isolated from the Antarctic lichen, a method for preparing the RAMALIN&#x2122;, and a pharmaceutical composition, a functional food and a functional cosmetic composition, which contain the RAMALIN&#x2122; as an active ingredient. The RAMALIN&#x2122; according to the invention has significantly excellent antioxidant effects compared to commercially available antioxidants, and thus can be widely used in agents for treating oxidation-related diseases, anti-aging functional foods, functional cosmetic products for skin whitening and wrinkle reduction, etc.

Compound ramalin and use thereof

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Incheon, South Korea

Doc Kyu Kim