Pohang University of Science and Technology Foundation

Snu Rdb Foundation

Do Won Hwang

Dong Soo Lee

Yong Song Gho

Won Jong Kim

Jae Min Jeong

Su Chul Jang

Yun-Sang Lee

Hongyoon Choi

Se Jin Son

A method for labeling exosomes with a radioactive substance using an amine group on surfaces of the exosomes includes providing a cell-derived exosome, treating a surface of the exosome with N-hydroxysuccinimide-azadibenzocyclooctyne (NHS-ADIBO), and mixing the treated exosome with N3-introduced chelator-radioactive substance to conduct a reaction between the chelator and an amine group present on the surface of the exosome, wherein the radioactive substance is introduced inside the exosome by the above reaction. The exosomes can be stably labeled at high labeling efficiency, and the exosomes can be favorably used as an agent for nuclear medicine imaging and therapeutic imaging for confirming the biological distribution of exosomes and whether the exosomes move to target organs and target diseases in animals including a human being.

Method for labeling exosomes with radioactive substance and use thereof

The present invention provides a polynucleotide delivery system including a cationic polymer to which a rabies virus glycoprotein (RVG) peptide is bound, wherein the cationic polymer includes a biodegradable bond, and a method of delivering polynucleotides to a target cell by using the delivery system.

Polynucleotide delivering complex for target cell

Growing community of inventors

Incheon, South Korea

Do Won Hwang