Yonsei University

Cosmax Nbt, Inc.

Cosmax Ns, Inc.

Do Wan Kwon

Jin Hak Kim

Su Young Choi

Chang Hee Kim

Jae Kwan Hwang

Mi Bo Kim

Joon Hyung Lee

Jeong Ho Geum

Ji Hwan Jang

Jun Gon Yun

Min Son Kweon

The present invention relates to a composition for preventing or treating a muscle disorder, which includes a chrysanthemum extract or 3,5-dicaffeoylquinic acid as an active ingredient, and specifically, it may be used to reduce mRNA expression of atrogin-1 and MuRF1, which are main biomarkers involved in muscle protein degradation and increase mRNA expression of the mTOR protein, which is a main biomarker involved in muscle protein formation, and myogenin and MyoD, which are biomarkers related to muscle differentiation, thereby reducing muscle loss, and thus the chrysanthemum extract or 3,5-dicaffeoylquinic acid can be used in prevention and treatment of a muscle disorder, or improvement in muscle function. In addition, the chrysanthemum extract or 3,5-dicaffeoylquinic acid increases the activity of SIRT1 and PGC-1&#x3b1;, which are the main biomarkers involved in exercise performance, thereby excellently enhancing exercise performance. In addition, the present invention is a natural substance and may be safely used without a side effect, and therefore may be used as a medication, food or a cosmetic.

Composition for improvement of muscle function containing 3,5-dicaffeoylquinic acid or chrysanthemum extract

Growing community of inventors

Gyeongsangbuk-do, South Korea

Do Wan Kwon