Lupin, Inc.

Dnyaneshwar Changdeo Bhanage

Venkata Poornapragnacharyulu Palle

Rajender Kumar Kamboj

Neelima Sinha

Navnath Popat Karche

Anil Kashiram Hajare

Shridhar Keshav Adurkar

Baban Rupaji Thube

Disclosed is a compound of formula (I), wherein R, R, R, R, R, R, Rand m are as described herein, as a modulator of nicotinic acetylcholine receptors particularly &#x3b1;7 subtype, its tautomeric forms, its stereoisomers, its pharmaceutically acceptable salts, its pharmaceutical composition, and its combinations with suitable medicaments. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and therapy of disorders such as Alzheimer's disease, mild cognitive impairment, senile dementia, and the like. 

Pyrrole derivatives as alpha 7 nAChR modulators

Disclosed are compounds of the formula (I), wherein R, R, R, R, R, R, Rand m are as described herein, as modulators of the nicotinic acetylcholine receptors, particularly the &#x3b1;7 subtype, their tautomeric forms, stereoisomers, and their pharmaceutically acceptable salts, pharmaceutical compositions thereof, and combinations thereof with suitable other medicaments. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and/or treatment of disorders such as Alzheimer's disease, mild cognitive impairment, and senile dementia. 

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Pune, India

Dnyaneshwar Changdeo Bhanage