Mylan Laboratories Limited

Dnyandeo Punde

Ramakoteswara Rao Jetti

Anjaneyaraju Indukuri

Vinayak Gore

Rajendra Yadav

Yogesh Wakchaure

Chandersingh Bohra

Mahdeshkumar Gadakar

Mahesh Kumar Gadakar

The present disclosure provides a novel polymorph of an intermediate useful in the preparation of palbociclib. The polymorph has enhanced properties that influence process ability of the intermediate and synthesis of palbociclib.

Polymorph of an intermediate for palbociclib synthesis

The present disclosure provides novel crystalline forms of cabozantinib (S)-malate, designated as form-M, M, Mand Mand novel crystalline forms of cabozantinib free base, form-M, Mand Mand methods of their production. The present disclosure also provides processes for the preparation of crystalline cabozantinib (S)-malate form N-1.

Polymorphs of cabozantinib (S)-malate and cabozantinib free base

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Hyderabad Telangana, India

Dnyandeo Punde