Mutabilis

Dmytro Atamanyuk

Vincent Gerusz

Francis Chevreuil

Christophe Simon

Fabien Faivre

Nicolas Lecointe

Vivien Henryon

Francois Moreau

Benoît Ledoussal

Chrystelle Oliveira

Jerome Monbrun

Etienne Airiau

François Moreau

Jérôme Monbrun

The invention relates to the compounds (I) and their acids and bases salts: wherein: Formula (I) the dotted line indicates a double bond; X is N or C&#x2014;Rand Y is N or C&#x2014;R, X and Y not being simultaneously N; A is selected from the group consisting of phenyl, naphthyl and (5-11) membered monocyclic or bicyclic unsaturated cycle or heterocycle possibly substituted as defined in the application, and A can also comprise either a further (4-7) membered heterocycle, said heterocycle being a monocycle, fused, saturated or unsaturated, the polycyclic system then comprising up to 14 members and up to 5 heteroatoms selected from N, O and S; B is selected from the group of substituents as defined in the application, or B is a 4 or (6-10) membered mono or bicyclic saturated or unsaturated heterocycle containing 1-3 heteroatoms selected from N, O and S, linked by a carbon atom, and possibly substituted as defined in the application; Ris Hydrogen or a substituent as defined in the application; Ris Hydrogen or Halogen; their preparation, their use in the antibacterial prevention and therapy, alone or in association with antibacterials, antivirulence agents or drugs reinforcing the host innate immunity, and pharmaceutical compositions and associations containing them. 

Heteroaromatic derivatives and their use as pharmaceuticals

The invention relates to compounds of formulae (Ia), (Ib) or (Ic) wherein, Aand A, identical or different, are H, (C-C) alkyl, (C-C) fluoroalkyl, (C-C) alkenyl, (C-C) alkynyl, (C-C) alkyl-OR, (C-C) alkyl-SR, (C-C) alkyl-NRR, OR, SR, NRR, or COR; Ais H, OH or form a carbonyl with A; Ais H, OH or form a carbonyl with A; Ais H, CRROH, F, OH or forms a double bond with X in the case where X is CH; Ais H or F; X is CH, CHF, CF, CHOH, O, S, NRor a simple bond, or X is CH in the case where Aforms with X a double bond; Y is P(O)(OR)(OR) or P(O)(OR)(NRR); V is O or S; Ais H, (C-C) alkyl, (C-C) fluoroalkyl, (C-C) alkenyl, (C-C) alkynyl or (C-C) alkyl-OR; Ais OH or H, Rand R, identical or different, are H, (C-C) alkyl, (C-C) fluoroalkyl, (C-C) alkyl-OH or (C-C) alkyl-O&#x2014;(C-C) alkyl; and their addition salts thereof with acids and bases, their preparation and their use in the antibacterial prevention and therapy, used alone or in association with antibacterials, antivirulence agents or drugs reinforcing the host innate immunity. 

Antibacterial compounds and biological applications thereof

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Chelles, France

Dmytro Atamanyuk