University of California

Southwest Sciences, Inc.

Government of the United States of America, As Represented by the Secretary of Commerce

Stc.unm

Dmitry Budker

Micah Ledbetter

Alexander Pines

Shoujun Xu

David E Wemmer

David Christian Hovde

John Kitching

Svenja Knappe

Louis S Bouchard

James Higbie

Igor Mykhaylovych Savukov

Valeriy V Yashchuk

Andrejs Jarmola

Victor Marcel Acosta

Elad Harel

Brian Patton

Eric P Corsini

Thomas Lowery

Christian Hilty

Victor Acosta

Kasper Jensen

Vishal K Shah

David J Michalak

Lykourgos Bougas

Andrey Jarmola

Thomas L Lowery

Charles W Crawford

Technologies relating to a magnetic resonance spectrometer are disclosed. The magnetic resonance spectrometer may include a doped nanostructured crystal. By nanostructuring the surface of the crystal, the sensor-sample contact area of the crystal can be increased. As a result of the increased sensor-sample contact area, the output fluorescence signal emitted from the crystal is also increased, with corresponding reductions in measurement acquisition time and requisite sample volumes.

Magnetic resonance spectrometer

An FM-NMOR magnetometer and concomitant magnetometry method comprising providing a linearly-polarized pump beam generator, employing a center wavelength approximately equal to a center wavelength of hyperfine peaks, and employing a modulation amplitude in the range HFS-3&#xd7;LW to HFS.

Wavelength-modulated coherence pumping and hyperfine repumping for an atomic magnetometer

A solid-state gyroscope apparatus based on ensembles of negatively charged nitrogen-vacancy (NV) centers in diamond and methods of detection are provided. In one method, rotation of the NVsymmetry axis will induce Berry phase shifts in the NVelectronic ground-state coherences proportional to the solid angle subtended by the symmetry axis. A second method uses a modified Ramsey scheme where Berry phase shifts in theN hyperfine sublevels are employed.

Gyroscopes based on nitrogen-vacancy centers in diamond

An embodiment of a method of detecting a J-coupling includes providing a polarized analyte adjacent to a vapor cell of an atomic magnetometer; and measuring one or more J-coupling parameters using the atomic magnetometer. According to an embodiment, measuring the one or more J-coupling parameters includes detecting a magnetic field created by the polarized analyte as the magnetic field evolves under a J-coupling interaction.

Detection of J-coupling using atomic magnetometer

An optical atomic magnetometers is provided operating on the principles of nonlinear magneto-optical rotation. An atomic vapor is optically pumped using linearly polarized modulated light. The vapor is then probed using a non-modulated linearly polarized light beam. The resulting modulation in polarization angle of the probe light is detected and used in a feedback loop to induce self-oscillation at the resonant frequency.

Optical atomic magnetometer

A novel approach to magnetic resonance imaging is disclosed. Blood flowing through a living system is prepolarized, and then encoded. The polarization can be achieved using permanent or superconducting magnets. The polarization may be carried out upstream of the region to be encoded or at the place of encoding. In the case of an MRI of a brain, polarization of flowing blood can be effected by placing a magnet over a section of the body such as the heart upstream of the head. Alternatively, polarization and encoding can be effected at the same location. Detection occurs at a remote location, using a separate detection device such as an optical atomic magnetometer, or an inductive Faraday coil. The detector may be placed on the surface of the skin next to a blood vessel such as a jugular vein carrying blood away from the encoded region.

Magnetic resonance imaging of living systems by remote detection

A method and apparatus are described wherein a micro sample of a fluidic material may be assayed without sample contamination using NMR techniques, in combination with magnetoresistive sensors. The fluidic material to be assayed is first subject to pre-polarization, in one embodiment, by passage through a magnetic field. The magnetization of the fluidic material is then subject to an encoding process, in one embodiment an rf-induced inversion by passage through an adiabatic fast-passage module. Thereafter, the changes in magnetization are detected by a pair of solid-state magnetoresistive sensors arranged in gradiometer mode. Miniaturization is afforded by the close spacing of the various modules.

Detection of magnetic resonance signals using a magnetoresistive sensor

A magnetometer and concomitant magnetometry method comprising emitting light from a light source, via a pulse generator pulsing light from the light source, directing the pulsed light to an atomic chamber, employing a field sensor in the atomic chamber, and via a signal processing module receiving a signal from the field sensor.

Pulsed free induction decay nonlinear magneto-optical rotation apparatus

An integral microfluidic device includes an alkali vapor cell and microfluidic channel, which can be used to detect magnetism for nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI). Small magnetic fields in the vicinity of the vapor cell can be measured by optically polarizing and probing the spin precession in the small magnetic field. This can then be used to detect the magnetic field of in encoded analyte in the adjacent microfluidic channel. The magnetism in the microfluidic channel can be modulated by applying an appropriate series of radio or audio frequency pulses upstream from the microfluidic chip (the remote detection modality) to yield a sensitive means of detecting NMR and MRI.

Integrated microchip incorporating atomic magnetometer and microfluidic channel for NMR and MRI

A laser-based atomic magnetometer (LBAM) apparatus measures magnetic fields, comprising: a plurality of polarization detector cells to detect magnetic fields; a laser source optically coupled to the polarization detector cells; and a signal detector that measures the laser source after being coupled to the polarization detector cells, which may be alkali cells. A single polarization cell may be used for nuclear magnetic resonance (NMR) by prepolarizing the nuclear spins of an analyte, encoding spectroscopic and/or spatial information, and detecting NMR signals from the analyte with a laser-based atomic magnetometer to form NMR spectra and/or magnetic resonance images (MRI). There is no need of a magnetic field or cryogenics in the detection step, as it is detected through the LBAM.

Atomic magnetic gradiometer for room temperature high sensitivity magnetic field detection

Growing community of inventors

El Cerrito, CA, United States of America

Dmitry Budker