Medivir Ab

Tibotec Pharmaceuticals Ltd.

Janssen R&d Ireland

Medivir Aktiebolag

Dmitry Antonov

Bengt Bertil Samuelsson

Karl Magnus Nilsson

Pierre Jean-Marie Bernard Raboisson

Herman Augustinus De Kock

Kenneth Simmen

Åsa Annica Kristina Rosenquist

Christer Sahlberg

Christian Sund

Susana Ayesa Alvarez

David Craig McGowan

Abdellah Tahri

Pia Kahnberg

Hans Kristian Wallberg

David Craig Mc Gowan

Carl Erik Daniel Jönsson

Anna Karin Gertrud Linnea Belfrage

Rolf Nor&eacute;en

Stefan Lindstrom

Lourdes Salvador Odén

Björn Olof Classon

Pierre Jean-Marie Bernard Rabiosson

Mats Stefan Lindström

Stefan Lindström

Nathalie Roue

Katarina Jansson

Kenneth Alan Simmen

ÅSa Annica Kristina Rosenquist

Pia Cecilia Kahnberg

Åsa Annica Kristina Rosenquist

Inhibitors of HCV replication of formula (I) the N-oxides, salts, and stereochemically isomeric forms thereof, wherein each dashed line (represented by) represents an optional double bond;

Macrocyclic inhibitors of hepatitis C virus

Compounds of the formula I: including a stereoisomer thereof, or an N-oxide, a pharmaceutically acceptable addition salt, or a pharmaceutically acceptable addition solvate thereof; useful as HCV inhibitors; processes for preparing these compounds as well as pharmaceutical compositions comprising these compounds as active ingredient.

HCV inhibiting macrocyclic phenylcarbamates

Inhibitors of HCV of formula (I). and the N-oxides, salts, and stereoisomers thereof, wherein the dashed line represents an optional double bond between atoms C7 and C8; Ris hydrogen or Calkyl; Ris hydrogen or Calkyl; and n is 3, 4, 5, or 6;pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I) are provided. Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavir are also provided.

Compounds of the formula Z: where; A is CH or N; Ris a substituent to a carbon atom in the ring containing A selected from &#x2014;S(&#x2550;O)Ra, where Ra is &#x2014;C-Calkyl, &#x2014;ORx, &#x2014;NRxRx, &#x2014;NHNRxRx, &#x2014;NHNHC(&#x2550;O)ORx, &#x2014;NRxOH; &#x2014;C(&#x2550;O)&#x2014;Rb, where Rb is &#x2014;CT-C4-alkyl, ORx, &#x2014;NRxRx, &#x2014;NHNRxRx, &#x2014;NHC-C-alkyl-C(&#x2550;O)Orx &#x2014;NRxRc, where Rc is H, C-Calkyl, &#x2014;NRxRx; &#x2014;C(=0)Rd, &#x2014;CN, S(&#x2550;O)pRx, where Rd is Rd is C1-C4-alkyl, &#x2014;ORx, &#x2014;NRxRx C-C-alkyl-O&#x2014;C1-C3-alkylC(&#x2550;O)ORx, &#x2014;C-C-alkyl-COORx; &#x2014;C-Calkyl-OH or C-Calkyl ethers or esters thereof (O&#x2014;C-Calkyl)q-O&#x2014;Rx a 5 or 6 membered aromatic ring having 1-3 hetero atoms p is 1 or 2; Rx is independently selected from H, C-Calkyl or acetyl; or a pair of Rx can together with the adjacent N atom form a ring; L is -0-, &#x2014;S(&#x2550;O)&#x2014;, or &#x2014;CH&#x2014;, where r is 0, 1 or 2; R-Rare substituents as defined in the specification; X is &#x2014;(CRR')n-D-(CRR&#x2032;)m-; D is a bond, &#x2014;NR&#x2014;, -0-, &#x2014;S&#x2014;, &#x2014;S(=0)- or &#x2014;S(=0)-; and pharmaceutically acceptable salts and prodrugs thereof, have utility as HIV antivirals. 

Non-nucleotide reverse transcriptase inhibitors

Inhibitors of HCV replication of formula (I) and the N-oxides, salts, or stereoisomers thereof, wherein

A compound of the formula (Y): where; Ris O, S; Ris a nitrogen-containing heterocycle; Ris H, C-Calkyl; X is &#x2014;(CRR')-D-(CRR&#x2032;)&#x2014;; D is a bond, &#x2014;NR&#x2014;, &#x2014;O&#x2014;, &#x2014;S&#x2014;, &#x2014;S(&#x2550;O)&#x2014; or &#x2014;S(&#x2550;O)&#x2014;; n and m are independently 0, 1 or 2, Rand R&#x2032; are independently H, C-Calkyl, haloC-Calkyl, hydroxy, or Rand R&#x2032; together with their adjacent C atom is &#x2014;C(&#x2550;O)&#x2014;; Ris independently H, C-Calkyl; E is CH&#x2014;, &#x2014;CHOH&#x2014;, &#x2014;C(&#x2550;O)&#x2014;, &#x2014;NR&#x2014;, &#x2014;O&#x2014;, &#x2014;S&#x2014;, &#x2014;S(&#x2550;O)&#x2014;; n and m are independently 0, 1 or 2; p and q are independently 0, 1 or 2, where p+q&#x2266;2; Ris an optionally substituted carbocycle or heterocycle; Ris independently H, C-Calkyl, halo substituted C-Calkyl, hydroxy; have utility as HIV antivirals.

Non-nucleoside reverse transcriptase inhibitors

Growing community of inventors

Huddinge, Sweden

Dmitry Antonov