The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth, Near Dublin

Dmitriy Kashanin

Igor V Shvets

Vivienne Williams

Dermot P Kelleher

Yuri Volkov

Biological assays using various constructions of biochips are disclosed to mirror in vivo situations. The biochipcomprises a microchannelhaving a liquid outlet port, bubble release portand a liquid outlet portwith an associated bubble release port. A multiplicity of tests can be performed often by coating the bore of the microchannelwhich various adhesion mediating proteins or the use of chemoattractants. The assay assemblycomprises a syringe pump feeding the biochip. An inverted microscope, digital cameraand recorderare provided. A sample liquid containing cells in suspension is injected slowly through the biochip and the effect of the assay recorded over a long period.

Method of assaying cellular adhesion with a coated biochip

Biological assays using various constructions of biochips are disclosed to mirror in vivo situations. The biochip comprises a microchannel having a liquid outlet port , bubble release port and a liquid outlet port with an associated bubble release port . A multiplicity of tests can be performed often by coating the bore of the microchannel which various adhesion mediating proteins or the use of chemoattractants. The assay assembly comprises a syringe pump feeding the biochip . An inverted microscope , digital camera and recorder are provided. A sample liquid containing cells in suspension is injected slowly through the biochip and the effect of the assay recorded over a long period.

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Dublin, Ireland

Dmitriy Kashanin