Octapharma Ag

Bia Separations D.o.o.

Bia D.o.o. Laboratory and Process Equipment Co., Ltd.

Djuro Josic

Ales Strancar

Monika Stadler

Gerhard Gruber

Primoz Koselj

Ales Podgronik

Horst Schwinn

Werner Gehringer

Andrea Buchacher

Frederic Bal

Milos Barut

Ales Podgornik

Frank Morfeld

Lutz Hoffer

A process for preparing a hemostatically active preparation containing von Willebrand factor (vWF) from a fraction of human plasma by chromatographic purification of a vWF-containing plasma fraction on an anion-exchange material which has the anion-exchanging groups on grafted polymeric structures (tentacle materials), collecting a vWF-containing fraction, followed by purification of said fraction using gel permeation to prepare a purified thermally stable vWF-containing preparation; and heating the preparation for inactivating viruses.

Hemostatically active vWF-containing preparation and process for the preparation thereof

Haemostatically active preparation containing vWF and method for the production thereof

Disclosed is a process for preparing agents containing virus-inactivated vitamin K-dependent plasma components as well as protein C, protein S, factors II, VII, IX and/or X as well as combinations thereof, such as, for example, PPSB preparations, wherein a source containing these components is subjected to a appropriate separation procedures, especially by using membrane-chromatographic methods.

Process for preparing virus-inactivated factors 1X and X by membrane chromatography

Chromatographic device

A method for the inactivation of viruses, in particular those having no lipid coats, in protein-containing compositions from blood, blood plasma or similar natural sources by treating said source, simultaneously or succesively, with an effective amount of dialkyl or trialkyl phosphates and optionally surfactants at an elevated temperature in the range of from 55&deg; C. to 67&deg; C. for five hours to 30 hours.

Method for the inactivation of non-lipid-coated viruses

A device for the rapid separation and/or conversion of substrates is disclosed herein. The device include a porous tube (,) disposed inside a tubular sample distributor (,). The tubular sample distributor (,) includes channel structures on its inner surface and is disposed inside a tubular body (,). A tubular sample collector (,) having channel structures on its outer surface is disposed inside the porous tube (,). A circular sample distributor (,) is provided having a circumferential portion and radially extending grooves in conjunction with the channel structures of the tubular sample distributor (,). A circular sample collector (,) is also provided having a circumferential portion and radially extending grooves in conjunction with the channel structures of the tubular sample collector (,). The hollow body (,) is arranged between securing means (,) that provide a sample inlet and outlet in communication with the circular sample distributor (,) and circular sample collector (,), respectively.

Device for the rapid separation and/or conversion of substrates

Process for testing suitability of protein fractions containing factor

An apparatus for the conversion of substrates both for analytical and preparative purposes in a flow-through and cross-flow reactor having compact porous discs and/or compact porous tubes as carrier for conversion reaction or preparative separations which compact porous discs and/or compact porous tubes are modified with substances being capable of specifically binding and/or converting said substrates by distributing the samples to be converted and/or preparatively separated and collecting the converted and/or separated substrates preferably in a low volume, wherein the distribution of the sample does not affect the carrier adversely.

Porous tube filter

Process for the preparation of factor IX from biological sources

Growing community of inventors

Vienna, Austria

Djuro Josic