Uniao Brasileira De Educacao E Assistencia-mantenedora Da Pucrs

Diógenes Santiago Santos

Luiz Augusto Basso

Pablo Machado

Daiana Renck

The use of at least one compound of formula I or II or pharmaceutically acceptable salts thereof, for preparing a pharmaceutical composition that acts by inhibiting the phosphorylase uridine enzyme, and the use of the compounds for preparing a pharmaceutical composition that acts by inhibiting the human phosphorylase uridine enzyme, which can be optionally used in combination with at least one antineoplastic, wherein the inhibition increases the effectiveness of antineoplastic and decreases the side effects caused by the administration of antineoplastics. 

Use of 6-hydroxy-2-pyridones and derivatives thereof for preparing a pharmaceutical composition that acts by inhibiting the human uridine phosphorylase enzyme

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Porto Alegre, Brazil

Diógenes Santiago Santos