Council of Scientific and Industrial Research

Divya Singh

Ritu Trivedi

Girish Kumar Jain

Naibedya Chattopadhyay

Avinash Kumar

Jyoti Gautam

Vikram Khedgikar

Amit Kumar

Rakesh Maurya

Anil Kumar Dwivedi

Rajender Singh Sangwan

Man Mohan Singh

Atul Goel

Neelam Singh Sangwan

Prabhat Ranjan Mishra

Sumit Chaurasia

Lakshmi Manickavasagam

Dharmendra Choudhary

Sulekha Adhikary

Rashmi Pandey

Abnish Kumar Gautam

Shelendra Pratap Singh

Wahajuddin

Preety Dixit

Prabodh K Trivedi

Shweta Sharma

Ashwni Verma

Anirudha Karvande

Priyanka Kushwaha

Sheelendra Pratap Singh

A method for prevention and/or treatment of diminution of bone tissue using a composition comprising a compound selected from Withaferin A (WFA), Withanolide A, and Withanone. The composition showed enhanced WFA bioavailability in rodents against plain WFA, promotes bone marrow cell differentiation, and increases the percent of bone volume to tissue volume (BV/TV %) by 3 folds as compared to free Withaferin A (WFA).

Pharmaceutical composition for the treatment of diminution of bone tissue

The present invention relates to bioactive fractions and compounds fromfor the prevention or treatment of osteo-health related disorders. The present invention relates in the field of pharmaceutical composition that provides new plant extracts, their fractions and pure compound isolated from natural sources that are useful for the prevention and/or treatment of various medical indications associated with estrogen dependent or independent diseases or syndromes or disorders preferably in the prevention or treatment of estrogen dependent or independent diseases or syndromes or disorders caused in humans and animals, and achievement of peak bone mass during skeletal growth and health in humans and animals. Particularly the present invention further relates to the processes for the preparation of biologically active extracts, fractions, and isolation of pure compounds, fromplant from the family Fabaceae their pharmaceutically acceptable salts and compositions of the principal aspect of the present invention.

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The present invention relates to novel substituted benzfurochromenes and related compounds having the general formula (I), salts and chiral, achiral derivatives thereof; wherein R, R, R, R, R, R, R, Rare independently selected from the groups consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkoxyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkylthio, optionally substituted amino, optionally substituted acylamino, optionally substituted arylamino, optionally substituted acylthio, optionally substituted acyl, optionally substituted aroyl, optionally substituted acyloxy, optionally substituted thioamido, halogens, nitriles, esters, hydroxy, mercapto, carbontrifluoride, nitro but not limited to this; wherein RRor RRor RRmay be connected and form either a five membered ring or a six membered ring such as optionally substituted furan, optionally substituted dihydrofuran, optionally substituted pyran; or may be connected through a methylenedeoxy moiety; wherein X is selected from the units consisting of optionally a ketone group, optionally a methylene group, optionally substituted methylene group, optionally substituted alkene; wherein Y and Z is selected from the units consisting of CH, C&#x2014;OH, C-Me, C&#x2014;OMe with the proviso that bond between Y and Z is a single bond; Wherein Y and Z may be a carbon atom with the proviso that bond between Y and Z is a double bond. The compounds of the general formula is useful for the prevention and treatment of bone related disorders. 

Substituted benzfurochromenes and related compounds for the prevention and treatment of bone related disorders

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Lucknow, India

Divya Singh