Boston University

The General Hospital Corporation

Divya Israni

Ahmad S Khalil

J Keith Joung

Jeffry D Sander

Wilson Wai Chun Wong

Huishan Li

Minhee Park

The technology described herein is directed to regulated synthetic gene expression systems. In one aspect described herein are synthetic transcription factors (synTFs) comprising a DNA binding domain, a transcriptional effector domain, and a regulator protein. In other aspects described herein are gene expression systems comprising said synTFs and methods of treating diseases and disorders using said synTFs.

Regulated synthetic gene expression systems

Embodiments disclosed herein provide artificial expression systems comprising the zinc-finger containing transcription factors and engineered promoters to modulate expression of genes of interest. Engineered zinc-finger transcription factors that interact with engineered promoters constitute synthetic and regulatable expression systems which facilitate the modulation of gene expression as desired.

Synthetic transcriptional and epigenetic regulators based on engineered, orthogonal zinc finger proteins

Growing community of inventors

Boston, MA, United States of America

Divya Israni