Wyeth

Dana-farber-cancer Institute Inc.

Divya Chaudhary

Gordon James Freeman

Clive R Wood

Mark L Stahl

Lidia Mosyak

Lori J Fitz

William Stuart Somers

Laura Lin

Stephane Olland

Zhang Bao Xu

Karl Malakian

Scott Wolfrom

Julie Lee

Rita Greco

Disclosed are screening assays for identifying compounds which modulate the activity of, or signaling via, B7-4, or PD-1, especially which modulate the binding of B7-4 or PD-1 to a target molecule.

Methods for screening for compounds that modulate PD-1 signaling

A three-dimensional structure of human protein kinase C theta (PKC&#x3b8;) can be used in methods of designing an agent that interacts with PKC&#x3b8;. The agent can be an inhibitor of PKC&#x3b8; activity.

Structure of protein kinase C theta

Disclosed are screening assays for identifying compounds which modulate the activity of, or signaling via, B7-4, or PD-1, especially which modulate the binding of B7-4 or PD-1 to a target molecule Further disclosed are a vaccine and also other compositions which contain agents that modulate signaling via PD-1.

Methods for screening for compounds that modulate pd-1 signaling

Growing community of inventors

Andover, MA, United States of America

Divya Chaudhary