Allied Corporation

Alliedsignal Inc.

Allied Chemical Corporation

Divakaran Masilamani

Milorad M Rogic

Andiappan K Murthy

George S Hammond

Edward H Manahan

Mariann E Lucas

David M Hindenlang

Shaul M Aharoni

Fred J Gefri

Novel fluorogenic and chromogenic three-dimensional ionophores are provided which selectively bond ions such as potassium, sodium, and lithium, even in neutral aqueous or alcohol media. The novel ionophores comprise an 'ion-recognizing system' fused to a 'signal-moiety' through one or more heteroatoms having a non-bonded electron pair. The signal-moieties are selected from the group consisting of fused ring heterocyclics, fused aromatics, and subsituted aromatics having at least one nitro or azo moiety. The ion-recognizing system is a three-dimensional cryptand. The ionophores are ideal for the selective and direct termination of ions in biological or environmental samples and the like.

Fluorgenic and chomogenic three-dimensional ionophores as selective

The present invention is directed to a process of oxidizing organic compounds having allylic or benzylic carbon atoms. The process of this invention comprises reacting an organic compound having one or more allylic or benzylic carbon atoms with an effective amount of an effective oxidizing agent in water at a temperature equal to or greater than about 350.degree. C. and at a pressure equal to or greater than about 175 atmospheres, wherein said agent is selected from the group consisting of elemental sulfur, an oxidized form of elemental sulfur and, an organic or inorganic compound capable of forming elemental sulfur or said oxidized forms in situ under process conditions.

Oxidation of organic compounds having allylic or benzylic carbon atoms

The present invention is directed to a process of oxidizing organic compounds having benzylic carbon atoms. The process of this invention comprises reacting an organic compound having one or more benzylic carbon atoms with an effective amount of an effective oxidizing agent in water at a temperature equal to or greater than about 350.degree. C. and at a pressure equal to or greater than about 175 atmospheres, wherein said agent is selected from the group consisting of a combination of one or more bases and one or more of elemental sulfur, an oxidized form of elemental sulfur and/or an organic or inorganic sulfur containing compounds capable of forming elemental sulfur, said oxidized forms or a combination thereof in situ under process conditions, and organic or inorganic compounds which form one or more bases and elemental sulfur, oxidized forms of sulfur or a combination thereof in situ under process conditions.

Oxidation of organic compounds having benzylic carbon atoms in water

Novel fluorogenic ionophores have been synthesized which selectively bind ions such as potassium and sodium, even in neutral aqueous and alcoholic media and respond to such binding by fluorescence quenching or enhancement. These ionophores are ideal for the selective and direct determination of ions in biological or environmental samples and the like. The ionophores are also suitable for incorporation into fiber optic-based sensors for the continuous in vivo or in vitro monitoring of metal ions in blood or other biological fluids.

Ion selective fluorogenic reagents

An improved process for the production of methyl ethers of the type in which methanol is reacted with a branched monoolefin in the presence of a catalytically effective amount of one or more acid catalyst, said improvements comprising carrying out said reaction in one or two steps in the presence of one or more liquid organic compounds having one or more hydroxy substituents which functions as a carrier for the branched monoolefins. The hydroxy compound also inhibits the polymerization of the branched monoolefins.

Process for the production of methyl ethers from branched monoolefins

A novel process is described for the production of aliphatic ketones and an optional consequetive production of the corresponding carbinols. The starting reactants comprise ketones or aldehydes or compounds capable of converting to these in situ, such as alcohols. The reaction takes place in the presence of hydrogen in a selective temperature range, utilizing a catalyst comprising copper oxide.

Process for the production of ketones and carbinols

This invention relates to a process for preparing keto-cyano alkane compounds by treating the corresponding alpha substituted cycloalkanone compound with oxygen and ammonia in the presence of a transition metal catalyst.

Catalytic method of preparing keto-cyano alkane compounds

A process for preparing extended chain polyesters, and block or graft polyester or copolyesters by forming an intimate mixture of one or more polyesters and an effective amount of one or more phosphite compounds, and thereafter heating the intimate mixture at a temperature and for a time sufficient to form the desired amount of the desired polyester or co-polyester.

Process for preparing extended chain polyesters and block or graft

Processes for the autoxidative cleavage of selected ketones such as C.sub.4 -C.sub.10 cycloalkanones having at least one hydrogen or at least one R group on a carbon alpha to the carbonyl carbon or aryl alkyl ketones having the formula III ##STR1## comprising contacting a liquid phase comprising said ketone with elemental oxygen gas, preferably air, in the presence of a pulverized alkali metal hydroxide at a temperature of no more than 50.degree. C. for a time sufficient to produce an oxidized product are disclosed. Preferred cycloalkanones, 2-alkyl- and 2-arylcyclohexanone are autoxidized in pulverized sodium hydroxide/dimethoxyethane to produce 6-alkyl- or 6-aryl-6-oxohexanoic acids, respectively.

Autoxidative cleavage of ketones in the presence of pulverized alkali

Methanol is reacted with branched monoolefins such as isobutylene, or mixtures of hydrocarbons such as mixed C-4's from or in a refinery, in the presence of methanesulfonic acid. A column (10) operation is described wherein methanesulfonic acid (11) and methanol (12) are fed in countercurrent fashion to hydrocarbons (13). Crude product ether is removed as a liquid sidestream (25) above the feed of methanesulfonic acid (11), while hydrocarbons depleted of the reactive branched monoolefins (24) are removed overhead. The methanesulfonic acid suppresses the vapor pressure of methanol relative to product ether.

Producing methyl ethers of branched monoolefins

A process for preparing substituted or unsubstituted benzoxazoline compound by reacting ammonia, a cycloalkanone and oxygen in the presence of metal cations.

Novel spiro oxazoline compounds and methods for their preparation and use

Sulfuryl chloride is reacted in the liquid phase with an organic reactant which is a ketone or aromatic alcohol unsubstituted on both ortho carbons in the presence of a moderator selected from the group consisting of aliphatic alcohols of 1-3 carbons and aliphatic ethers of 2-6 carbons, with sufficient moderator being present to selectively produce a product substantially free of compounds with more than one chlorine atom per carbonyl or aromatic hydroxy. The products, such as monochloroacetone, monochlorocyclohexanone, monochlorophenol and 2,2-bis(3-chloro-4-hydroxyphenyl)propane, are useful as chemical intermediates and as monomers for flame retardant polymers.

Selective monochlorination of ketones and aromatic alcohols

Alkyl cyclohexa-1,3-dienes are aromatized with sulfur dioxide and oxygen. Cyclohexa-1,4-dienes are aromatized with sulfur dioxide. Conjugated dienic hydrocarbons, including alkyl cyclohexa-1,3-dienes, are converted to beta-olefinic peroxides by sulfur dioxide and oxygen. The aromatization reactions are useful as part of the synthesis of selected aromatics from acyclic olefins. The beta-olefinic peroxides are useful intermediates in the production of 1,4-diols.

Aromatization of dienes in the liquid phase

A process for regioselective isomerization of organic compounds having a carbon-carbon double bond at a tertiary carbon atom by sulfur dioxide induced allylic rearrangement of a hydrogen atom and/or replacement of a proton in the allylic position by a deuteron. The organic compound is contacted with sulfur dioxide at temperatures between about 0.degree. and 70.degree. C. for a time sufficient to effect such isomerization to a more stable isomer; and if deuteration is to take place D.sub.2 O is provided in the solution.

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Morristown, NJ, United States of America

Divakaran Masilamani