Boehringer Mannheim Gmbh

Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Dittmar Schlieper

Urban Schmitt

Barbara Upmeier

Volker Klemt

Frederic Donie

Franz Schmid

Helmut Lenz

Michael Wiedmann

Arno Deger

Martin Kaufmann

Michael Berger

Fran&ccedil;ois Guillot

The invention concerns the use of intramolecularly, covalently cross-linked proteins and covalently cross-linked reverse transcriptase from HIV as immunological binding partners in immunoassays. It also concerns immunological test procedures for detecting an analyte in a sample in which intramolecularly, covalently cross-linked proteins are used as binding partners, and it further concerns intramolecularly, covalently cross-linked reverse transcriptase from HIV and a method for producing this reverse transcriptase.

Use of intramolecularly, covalently cross-linked proteins as binding partners in immunoassays

The invention concerns a homogeneous immunoassay based on agglutination using an Fab&prime;-biotin material and agglutinatable particles which carry streptavidin or avidin. The invention also concerns the Fab&prime;-biotin which is bound or linked via linkage groups to a label compound which can electrochemiluminescence and the particles having avidin or streptavidin on their surface are magnetic.

Method for carrying out a homogeneous-immunoassay based on agglutination

Acylated protein aggregates and their use as signal enhancers in an

Antibody class-specific interference eliminating reagent

Elimination of rheumatoid factor interference using anti-FD antibodies

Acylated protein aggregates and their use in suppressing interference in

Growing community of inventors

Iffeldorf, Germany

Dittmar Schlieper