Sequenom, Inc.

Dirk Van Den Boom

Christian Jurinke

Andreas Braun

Hubert K&ouml;ster

Hubert Koster

Hubert Köster

Daniel P Little

Andreas Ruppert

Dong-Jing Fu

Norman Chiu

Liyan He

Charlie Rodi

Yip Ping

Kai Tang

Carsten W Siegert

Brigitte Darnhofer-Demar

Hubert Koester

Processes and methods for creating a database of genomic samples from healthy human donors, methods that use the database to identify and correlate polymorphic genetic markers and other markers with diseases and conditions are provided.

Methods for generating databases and databases for identifying polymorphic genetic markers

A method for detecting methylated nucleotides within a nucleic acid sample is provided. The method includes the steps of splitting a nucleic acid sample into separate reaction vessels; contacting nucleic acid in one reaction vessel with bisulfite; amplifying the nucleic acid in each reaction vessel; cleaving the nucleic acids in each reaction vessel to produce fragments thereof; and obtaining a mass spectrum of the resulting fragments from one reaction vessel and another mass spectrum of the resulting fragments from another reaction vessel.

Methods for detecting methylated nucleotides

The invention provides fast and highly accurate mass spectrometer based processes for detecting a particular nucleic acid sequence in a biological sample. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity.

DNA diagnostics based on mass spectrometry

A method for dissociating a complex of a biotin compound and a biotin-binding compound, by contacting the complex with an amine, is disclosed.

Method for dissociating biotin complexes

Processes and kits for simultaneously amplifying and sequencing nucleic acid molecules, and perfonning high throughput DNA sequencing are described.

Process for direct sequencing during template amplification

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Dreieich, Germany

Dirk Van Den Boom