Sanofi Pasteur Sa

Biomarin Pharmaceutical Inc.

Merck Eprova Ag

Dirk Spielvogel

Pierre Martin

Dietmar Flubacher

Andreas Boudier

Markus Mueller

Rudolf Moser

Viola Groehn

Andreas Schumacher

The present invention relates to a process for preparing a porphyrin of formula (I), optionally in the form of a salt with an alkali metal and/or in the form of a metal complex: in which: in which R'b is as defined above for (I), in which R&#x2033; is as defined in claim, and also the compounds of formula (III).

Process for preparing prophyrin derivatives, such as protoprophyrin (IX) and synthesis intermediates

The present invention relates to a process for preparing a porphyrin of formula (I), optionally in the form of a salt with an alkali metal and/or in the form of a metal complex: in which: in which R'b is as defined above for (I),and a dipyrromethane of formula (III): in which R&#x2033; is as defined in claim, and also the compounds of formula (III).

Process for preparing porphyrin derivatives, such as protoporphyrin (IX) and synthesis intermediates

Process for the preparation of tetrahydrobiopterin from neopterin and/or 6-substituted pterins with an improved yield and a high stereoselectivity. Also disclosed herein are novel individual intermediates prepared in the preparation of tetrahydrobiopterin, such as selectively protected neopterin useful for the preparation of tetrahydrobiopterin.

Process for preparing tetrahydrobiopterin and analogs of tetrahydrobiopterin

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Lorach, Germany

Dirk Spielvogel