Friedrich Miescher Institute for Biomedical Research

Novartis Forschungsstiftung, Zweigniederlassung

Dirk Schuebeler

Botond Roska

Josephine Juettner

Arnaud Krebs

Dominik Hartl

Michaël Philippe Weber

The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid sequence of at least 300 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule specifically leads to the expression in rod photoreceptors of a gene when operatively linked to a nucleic acid sequence coding for said gene.

Expression cassette with a SynP160 promoter

The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid sequence of at least 150 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule specifically leads to the expression in rod photoreceptors of a gene when operatively linked to a nucleic acid sequence coding for said gene.

SYNP161, a promoter for the expression of genes

SYNP162, a promoter for the expression of genes

The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid sequence of at least 400 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule specifically leads to the expression in rod photoreceptors of a gene when operatively linked to a nucleic acid sequence coding for said gene.

SynP159, a promoter for the expression of genes

The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid sequence of at least 400 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule specifically leads to the expression in direction selective retinal ganglion cells of a gene when operatively linked to a nucleic acid sequence coding for said gene.

SynP198, a promoter for the specific expression of genes in direction selective retinal ganglion cells

SYNP162, a promoter for the specific expression of genes in rod photoreceptors

SYNP159, a promoter for the specific expression of genes in rod photoreceptors

SynP160, a promoter for the specific expression of genes in rod photoreceptors

SynP161, a promoter for the specific expression of genes in rod photoreceptors

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Basel, Switzerland

Dirk Schuebeler