Immunex Corporation

Other

Amgen Inc.

Dirk M Anderson

G Duke Virca

Kenneth H Grabstein

Timothy A Bird

Charles Rauch

Laurent J Galibert

Victor Fung

June R Eisenman

Eugene Maraskovsky

Judith G Giri

Unja Martin

John Ernest Sims

Douglas Pat Cerretti

David J Cosman

William C Dougall

Alf D Larsen

Luis G Borges

Paul E Baker

Steven D Gimpel

Michael A Cantrell

Kate N McKereghan

John S Marken

Byron M Gallis

Robert J Tushinski

Described herein are cell lines and methods for preparing antibodies that bind RANKL, including cell lines that produce blocking antibodies to human RANKL.

RANK ligand polypeptides

Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof.

Receptor activator of NF-kappaB

Cells and methods for producing blocking antibodies to human RANKL

Methods for inhibiting osteoclastogenesis by administering a soluble RANK polypeptide are disclosed. Such methods can be used to treat a variety of different cancers, including bone cancer, multiple myeloma, melanoma, breast cancer, squamous cell carcinoma, lung cancer, prostate cancer, hematologic cancers, head and neck cancer and renal cancer.

Method of inhibiting osteoclast activity

Kits for detecting rank

Kits for detecting rank nucleic acids

The present disclosure provides attractin/mahogany-like polypeptides and fragments thereof, polynucleotides encoding such polypeptides and fragments, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides or fragments, and assays and methods employing these polypeptides, antibodies, and polynucleotides.

Attractin/mahogany-like polypeptides

A new family of immunoreceptor molecules of the immunoglobulin superfamily, (LIR) polypeptides is described. Disclosed are sequences encoding LIR family members and their deduced amino acid sequences, polypeptides encoded by DNA that hybridizes to defined nucleotide sequences, processes for producing polypeptides of the LIR family, and specific antibodies directed against LIR polypeptides. LIR family members can be used to treat autoimmune diseases and disease states associated with suppressed immune function.

LIR-9, a novel leukocyte immunoglobulin-like receptor

There are disclosed Interleukin-15 Receptor (IL-15R) proteins, DNAs and expression vectors encoding IL-15R, and processes for producing IL-15R as products of recombinant cell cultures.

Interleukin-15 receptors

Disclosed herein are methods for interfering with RANK signaling by administering blocking antibodies that bind a RANKL polypeptide and inhibit the binding of the RANKL polypeptide to a RANK polypeptide.

Methods for interfering with rank signaling

This invention relates to IMX97018, a new members of the human ataxin-1-like polypeptide family, methods of making such polypeptides, and to methods of using them to diagnose and treat neurological conditions and to identify compounds that alter IMX97018 polypeptide activities.

Antibodies binding to human ataxin-1-like polypeptide

Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.

Method of treating cancer by administering an epithelum-derived T-cell factor

Attractin/mahogany-like polypeptides, polynucleotides, antibodies and methods of use thereof

Disclosed herein are kits for detecting RANKL protein or nucleic acids, the kits comprising isolated human RANKL polypeptides, RANKL nucleic acids and/or antibodies specific for RANKL.

Monoclonal blocking antibody to human RANKL

Growing community of inventors

Seattle, WA, United States of America

Dirk M Anderson