Stichting Voor De Technische Wetenschappen

Rijksuniversiteit Groningen

Chromos Molecular Systems, Inc.

Synvolux IP B.v.

Stichting Scheikundig Ondoerzoek in Nederland

Dirk Hoekstra

Anno Wagenaar

Irene Van Der Woude

Sandra Louise Vanderbyl

Jan Bernard Frederik Nicolaas Engberts

Gary deJong

Marcel Herman Ruiters

Jan Bernard Engberts

Volker Oberle

Marcel Herman Jozef Ruiters

Methods for delivering nucleic acid molecules into cells and methods for measuring nucleic acid delivery into cells and the expression of the nucleic acids are provided. The methods are designed for introduction of large nucleic acid molecules, including artificial chromosomes, into cells, and are practiced in vitro and in vivo.

Methods for delivering nucleic acid molecules into cells and assessment thereof

Transport vehicles for macromolecules

The invention relates to new compounds with the general formula I for use as a tool to introduce macromolecules into cells. The invention further relates to compositions for introducing macromolecules into cells, comprising vesicles formed by at least one compound in a solvent. The macromolecule can be incorporated in the vesicles and/or bound to the vesicles or another aggregate of the new compounds. In a preferred embodiment at least one targeting molecule, for instance a (labelled) antibody, may further be attached to the vesicles. ##STR1##

Growing community of inventors

Zuidhorn, Netherlands

Dirk Hoekstra