Industrial Research Limited

Albert Einstein College of Medicine

Dirk Henning Lenz

Peter Charles Tyler

Gary Brian Evans

Vern L Schramm

Richard Hubert Furneaux

Olga Vladimirovna Zubkova

Keith Clinch

Jennifer Mary Mason

Richard Hurbert Furneaux

A process is disclosed for preparing (3R,4R)-3-hydroxy-4-hydroxymethylpyrrolidine, the compound of formula (I), or (3S,4S)-3-hydroxy-4-hydroxymethylpyrrolidine, the compound of formula (Ia) involving, as a key step, the enzyme-catalysed enantioselective hydrolysis of a racemic 3,4-trans-disubstituted pyrrolidinone compound of formula (II).

Method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds

The present invention relates to compounds of the general formula (I) which are inhibitors of purine muclioside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5'-methylthioadenosine phosphorylases (MTAP), 5&#x2032;-methylthioadenosine mucliosidases (MTAN) and/or nucleoside hydrolases (NH). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds.

Fused pyrimidines as inhibitors of nucleoside phosphorylases and nucleosidases

5h-pyrrolo[3,2-D] pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases

Growing community of inventors

Wellington, New Zealand

Dirk Henning Lenz