Janssen Pharmaceutica Nv

Dirk De Smaele

Stefan Marcel Leurs

Michel Joseph Maurice André Guillaume

Stefan Marcel Herman Leurs

Michel Joseph Guillaume

Yolande Lydia Lang

Armin Roessler

Jozef Ludo Jan Cuypers

Ivan Joseph Maria Vervest

Lars Ulmer

Rudy Laurent Broeckx

Ivan Joseph Vervest

Jozef Ludo Cuypers

The present invention relates to a novel process, suitable for industrial exploitation for the production of N-(2,6-dimethyl-phenyl)-2-piperazin-1-yl-acetamide, also known as N-lidocaine, obtained from the reaction of piperazine with N-haloacetyl-2,6-xylidine. The process comprises the consecutive steps a) through f)

Process for the production of n-(2,6-dimethyl-phenyl)-2-piperazin-1-yl-acetamide

The present invention relates to a novel process for the production of [2-(4-fluoro-benzyl)-phenyl]-acetic acid, a compound obtainable from phthalic anhydride. The process comprises the subsequent steps a) through e): In an alternative embodiment, the step e) is replaced by the steps f1) and f2): The present invention provides a process for the production of [2-(4-fluoro-benzyl)-phenyl]-acetic acid which is suitable for industrial scale reactors (e.g. which is cleaner and more efficient). Also, [2-(4-fluoro-benzyl)-phenyl]-acetic acid is obtained as a crystalline material with a purity &#x3e;95%.

Process for the production of [2-(4-fluoro-benzyl)-phenyl]-acetic acid

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Wetteren, Belgium

Dirk De Smaele