Hoechst Aktiengesellschaft

Behringwerke Aktiengesellschaft

Dirk Bottger

Gerhard Seibert

Werner Aretz

Peter Welzel

Alois Tumulka

Kurt Hobert

Hans P Kraemer

Hans G Berscheid

Cenek Kolar

Peter Hermentin

Michael Paal

Dieter Hoffmann

Hans-Jerg Kleiner

Gunter Roscher

Manfred Gerken

Harald Berger

Manfred Schmidt

Rainer Uhmann

Hans Peter Kraemer

Hans Gerd Berscheid

A new Bacillus species and the appropriate enzymes obtained therefrom can be used to break down phosphoglycolipid antibiotics. The breakdown products of moenomycins display antibiotic activity or can be used as building blocks for the synthetic preparation of transglycosylase inhibitors.

Bacillus strain for breaking down moenomycins

Process for the preparation of pure propanephosphonic anhydride, which comprises distilling crude, impure propanephosphonic anhydride having an average degree of polymerization of 20 to 200 and containing less than 0.5% by weight of water by heating to 230 to 300.degree. C. under a pressure of 0.1 to 100 mbar, pure propanephosphonic anhydride having an average degree of polymerization of 20 to 60 being obtained.

Process for the preparation of pure propanephosphonic anhydride

A new microorganism for breaking down moenomycins, a process for the breakdown, and the use of the breakdown products are disclosed. A new Bacillus species and the appropriate enzymes obtained therefrom can be used to break down phosphoglycolipid antibiotics. The breakdown products of moenomycins display antibiotic activity or can be used as building blocks for the synthetic preparation of transglycosylase inhibitors.

Microorganism for breaking down moenomycins, a process for the

A new Bacillus species and the appropriate enzymes obtained therefrom can be used to break down phosphoglycolipid antibiotics. The breakdown products of moenomycins display antibiotic activity or can be used as building blocks for the synthetic preparation of transglycosylas inhibitors.

Enzymes for breaking down moenomycins

2-alkenyloxy-3-(phosphono)oxypropanoic acids derived from the cleavage

The invention relates to new anthracycline derivatives having cytostatic activity and the general formula I, which are optionally in the form of a salt of an inorganic or organic acid, ##STR1## in which the substituents have the following meaning: R.sup.1 is hydrogen or a hydroxyl group,

Anthracycline derivatives having cytostatic activity

The invention relates to new anthracycline derivatives having cytostatic activity and the general formula I ##STR1## in which the radicals R.sup.1 is hydrogen or a hydroxyl group, R.sup.2 is hydrogen or a hydroxyl group or a structure of the formula II, and R.sup.3 is a hydroxyl group or a structure of the formula II ##STR2## in which R.sup.4 is an aliphatic or aromatic acyl group, with the proviso that at least one of the radicals R.sup.2 and R.sup.3 has a structure of the formula II, which are optionally in the form of a salt of an inorganic or organic acid, as well as to the process for the preparation thereof, and to the use thereof in pharmaceuticals.

The present invention relates to anthracycline derivatives and a process for their preparation. The compounds are distinguished by a high cytostatic activity and can therefore be used as medicaments with an anti-tumor action.

Anthracycline tetrasaccharides

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Hunstetten, Germany

Dirk Bottger