Council of Scientific and Industrial Research

Dipyaman Ganguly

Ayan Mukherjee

Arindam Talukdar

Biswajit Kundu

Swarnali Roy

Oindrila Rahaman

Barnali Paul

Santu Bandyopadhyay

Siddhartha Roy

Aditya Konar

Bikas Chandra Pal

Indrani Choudhury Mukherjee

Sanjit Kumar Mahato

Anirban Manna

Jayaraman Vinayagam

Shounak Roy

Churala Pal

Kausik Paul

Labanya Mandal

Srabanti Rakshit

Jayashree Bagchi Chakrabotry

Jaisankar Parasuraman

Roopkatha Bhattacharya

Amrit Raj Ghosh

Raychaudhuri Deblina

The present invention provides novel purine based compounds of formula 1, method of preparation of purine based compounds and its composition useful for inhibiting signalling through Toll-like receptors. These compounds are useful in inhibiting immune stimulation involving toll-like receptor 9 (TLR9). These can be used in treatment of autoimmune disease and inflammation where aberrant activation of TLR9 plays role. 

Purine based compounds as toll-like receptor 9 antagonist

The present invention relates to small molecule 4-(piperazin-1-yl)quinazolin-2-amino compounds with formula (I) useful for inhibiting signalling by certain toll-like receptors (TLRs), especially TLR9. Toll-like receptors (TLRs) are members of the larger family of evolutionarily conserved pattern recognition receptors which are critical first line of defense for self-nonself discrimination by the host immune response. Aberrant TLR9 activation is implicated in autoreactive inflammation in different autoimmune diseases. The invention depicts compounds with formula (I), composition and methods can be used in a number of clinical applications, including as pharmaceutical agents and methods for treating conditions involving unwanted immune activity due to TLR9 activation. 

Blocking toll-like receptor 9 signaling with small molecule antagonist

The present invention relates to compounds of general formula 1 for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention also relates to the use of compound of general formula 1 for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention further relates to a method of treating malignancy by inhibition of PI3-Akt pathway and or induction of NO by administration of compound or said composition to a mammal in need thereof.

Inhibitors of phosphatidylinositol-3-kinase (PI3) and inducers of nitric oxide (NO)

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Kolkata, India

Dipyaman Ganguly