Isp Investments Inc.

Dipan B Ray

Rama K Haldar

Sidney Etienne

William Drefko

John N Zamora

Timothy G Bee

Donald F Koelmel

Deborah Tobia

Su-Jane Cheng

Greg Dubrowny

Rama Haldar

A process for reducing the intensity of the intrinsic bitter taste of a water soluble active which comprises dry mixing of said active with &#x3b2;-cyclodextrin.

Process of reducing the bitter taste of water soluble actives by co-grinding the active with &#x3b2; cyclodextrin

Tablets of a pharmaceutical, nutritional or vitamin active compound or composition, e.g. a poorly compressible drug are made by direct compression using a synergistic binder composition of co-processed (a) copolymer of vinylpyrrolidone (VP) and vinyl acetate (VA) and (b) microcrystalline cellulose (MCC), in a wt. ratio of (a):(b) of 1-30:99-70, which is spray dried to provide a readily compressible excipient binder powder for such active. The tablets obtained herein have advantageous hardness and friability at an acceptable compression force.

Synergistic binder composition, method for making same, and tablets of an active and said binder having advantageous hardness and friability

Tablets of a poorly compressible drug are made by direct compression using a binder composition which is a polymer, preferably a copolymer of polyvinylpyrrolidone (PVP) and vinyl acetate (VA), having a defined glass transition temperature (Tg), admixed with a plasticizer, e.g. an organic ester or polyol, which reduces the Tg of the copolymer by at least 10&#xb0; C. The binder composition and the drug are directly compressed into a tablet of predetermined hardness and friability, and at an acceptable compression force.

Binder composition and method for processing poorly compressible drugs into tablets of predetermined hardness and friability

A process and apparatus for forming agglomerates of a powder composition of an active and binder such as a homopolymer or copolymer which includes passing the composition through a hot roller compactor to heat said binder material above its glass transition temperature.

Process and apparatus for forming agglomerates of a powder composition of an active and binder

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Springfield, NJ, United States of America

Dipan B Ray