Hoechst Aktiengesellschaft

Dipak K Chatterjee

Bindumadhavan Venugopalan

Bansi Lal

Richard H Rupp

Noel J De Souza

Pravin J Karnik

Chintamani P Bapat

Jurgen Blumbach

Bimal N Ganguli

Subramani N Iyer

Subramani N Iver

Balbir S Bajwa, Deceased

Jurgen Reden

Rajkumar Dhar

Compounds of formula I ##STR1## in which the substituted R has the given meaning, have an antimalarial and a antiviral activity.

9-substituted compounds of 3.alpha.,

10-substituted ether derivatives of 3.alpha., 12.alpha.-Epoxy-3,4,5 5a.alpha., 6,7,8,8a.alpha.,9,10,12.beta., 12a-dodecahydro-10-hydroxy-3.beta.,6.alpha.,9.beta.-trimethylpyano-(4,3-j) (1,2) benzodioxepin, also known as Dihydroartemisinin or Dihydroquinghaosu (DHQ), pharmaceutically acceptable salts thereof, processes for their preparation and their use as chemotherapeutics against protozoal infections are provided.

10-substituted ether derivatives of dihydroartemisinin, process for

The present invention relates to novel, 1-substituted 3-aryl-7-chloro-3,4-dihydro-(2H)-acridone N-oxides, a process for their preparation, pharmaceutical compositions containing these compounds, and their use as chemotherapeutic agents, in particular as antimalarials and coccidiostatics.

1-substituted 3-aryl-7-chloro-3,4-dihydro(2H)-acridone N-oxides, a

The present invention relates to new bisamidine derivatives of polycyclic compounds such as 5,10-dioxo-4,5,9,10-tetrahydro-4,9-dioxapyrene-6(5H)-phenanthridone and 5,10-dioxo-4,5,9,10-tetrahydro-4,9-dioxapyrenephenanthridine and to a process for their preparation. The polycyclic bisamidines according to the invention are distinguished by valuable chemotherapeutic properties, such as, for example, an action against amoebas and trichomonads.

Bisamidine derivatives of

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Bombay, India

Dipak K Chatterjee