Sanofi

Centre National De La Recherche Scientifique

Societe Anonyme Sanofi

Dino Nisato

Paolo Carminati

Sergio Boveri

Alberto Bianchetti

Emilio Crisafulli

Marco Frigerio

Romeo Roncucci

Henri Demarne

Jean Martinez

Luciano Manara

Bertrand Castro

Jean-Pierre Bali

Giovanna F Miranda

Roberto Sacilotto

The 3-aminoazetidine, its salts, new intermediates of formula ##STR1## wherein X' represents hydrogen or a protecting group and both X' represent hydrogen or, together with the nitrogen atom, a phthalimido group, X' and both X' not being hydrogen at the same time; a process for the preparation of the 3-aminoazetidine, starting from a 1-protected 3-sulfonyloxyazetidine by reaction with the potassium phthalimide and transformation of the above mentioned intermediates.

3-aminoazetidine, its salts, process for their preparation and

The 3-aminoazetidine, its salts, new intermediates of formula ##STR1## wherein X' represents hydrogen or a protecting group and both X' represent hydrogen or, together with the nitrogen atom, a phthalimido group, X' not and both X' being hydrogen at the same time; a process for the preparation of the 3-aminoazetidine, starting from a 1-protected 3-sulfonyloxyazetidine by reaction with the potassium phthalimide and transformation of the above mentioned intermediates.

3-aminoazetidine, its salts and intermediates of synthesis

Methyllevallorphanium salts having peripheral antagonistic activity of formula ##STR1## wherein Y.sup.n(-) represents the anion a pharmaceutically acceptable acid other than halogen and n represents the number of negative charges of said anion; a process for their preparation by exchange of the halogen ion with the Y.sup.n(-) anion; and pharmaceutical compositions containing them as active ingredients.

Methyllevallorphanium salts having peripheral opiate antagonistic

The invention relates to 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridines of formula ##STR1## in which R represents a cyano, acetyl or cycloalkyl group of from 3 to 7 carbon atoms and Alk represents a straight or branched alkylene of from 1 to 4 carbon atoms, as well as to the salts thereof, having an anorectic acitivity, to a process for preparing same and to pharmaceutical compositions containing said compounds, useful in the treatment of obesity.

Anorectic agent;

The invention relates to peptides of general formula:

Novel peptidic derivatives inhibiting gastric secretion, process for

The invention relates to 4-(-3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridines of formula ##STR1## in which R represents a cyano, acetyl or cycloalkyl group of from 3 to 7 carbon atoms and Alk represents a straight or branched alkylene of from 1 to 4 carbon atoms, as well as to the salts thereof, having an anorectic activity, to a process for preparing same and to pharmaceutical compositions containing said compounds, useful in the treatment of obesity.

Substituted trifluoromethylphenyltetrahydropyridines having a cyano

Benzamides having histamine H.sub.2 receptor blocking activity of formula ##STR1## wherein A represents O, S, N--CN or CH--NO.sub.2 and R represents an alkyl group or an optionally substituted phenyl, pyridyl or pyridyl 1-oxide group; their salts; a process for their preparation; and pharmaceutical compositions containing them as active ingredients.

3-Amino-n-[2-(5-dimethylaminomethylfuran-2-ylmethylthio)ethyl]benzamide

Novel 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridines of formula ##STR1## wherein R is an unsubstituted or by an alkyl group of from 1 to 4 carbon atoms substituted pyridyl, pyridyl 1-oxide or naphthyl group and Alk is a straight or branched chain alkylene group of from 2 to 4 carbon atoms are anorexigenic agents useful for treating obesity.

Anorexigenic trifluoromethylphenyltetrahydropyridines and pharmaceutical

N-substituted nicotinamide 1-oxide having histamine H.sub.2 receptor blocking activity of formula ##STR1## wherein X is a nitrogen atom or a CH group and Am represents a mono- or disubstituted amino group, a pyrrolidino, morpholino, thiomorpholino, hexamethyleneimino group, or an optionally substituted piperidino or piperazino group; their salts; a process for their preparation; and pharmaceutical compositions containing them as active ingredients.

N-substituted nicotinamide 1-oxide as histamine H.sub.2 receptor blockers

Amides acting as histamine H.sub.2 receptors antagonists, of formula ##STR1## wherein X represents a N.fwdarw.O or C-NH-A-B group in which A is CO or SO.sub.2 and B is alkyl, phenyl, pyridyl, pyridyl 1-oxide, pyrazinyl or thienyl; their salts; process for their preparation by reacting 2-(2-guanidinothiazol-4-ylmethylthio)ethylamine with a derivative of formula ##STR2## and optional salification; and pharmaceutical compositions containing same.

Certain amide derivatives of 2-guanidino-thiazoles and compositions

Benzamides, their salts, and pharmaceutical compositions containing them

The invention relates to thioalkylamide of nicotinic acid 1-oxide with H.sub.2 receptor blocking activity, of formula: ##STR1## and to its pharmaceutically acceptable salts, to a process for preparing same by reaction of 2-(5-dimethylaminomethylfuran-2-ylmethylthio)ethylamine with a functional derivative of nicotinic acid 1-oxide and possible salification, and to pharmaceutical compositions containing same.

Thioalkylamide of nicotinic acid 1-oxide, its salts, and pharmaceutical

The invention relates to 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridines of formula ##STR1## in which R represents a cyano, acetyl or cycloalkyl group of from 3 to 7 carbon atoms and Alk represents a straight or branched alkylene of from 1 to 4 carbon atoms, as well as to the salts thereof, having an anorectic activity, to a process for preparing same and to pharmaceutical compositions containing said compounds, useful in the treatment of obesity.

Substituted trifluoromethylphenyltetrahydropyridines having an anorectic

Amidobenzamides acting as histamine H.sub.2 receptors blocking agents, of formula ##STR1## wherein A is CO or SO.sub.2 and B is alkyl, phenyl, pyridyl, pyridyl-1-oxyde, pyrazinyl or thienyl; their salts; process for their preparation by reaching 2-(5-dimethyl-aminomethylfuran-2-ylmethylthio)ethylamine with a derivative of formula ##STR2## and optional salification and pharmaceutical compositions containing same.

Amidobenzamides, their salts and pharmaceutical compositions containing

The present invention relates to novel 4-amino-1-(2-pyridyl)piperidines with anorexiant action, of formula: ##STR1## in which R represents hydrogen, a halogen, a methyl group, a trifluoromethyl group, a lower alkoxy group, a trifluoromethoxy group, a 2,2,2-trifluoroethoxy group, a lower alkylthio group, a trifluoromethylthio group, a possibly substituted phenoxy group or a possibly substituted phenylthio group; to salts thereof; to a process for preparation thereof; to drugs containing same; and to intermediate products in the synthesis thereof.

Growing community of inventors

Pavia, Italy

Dino Nisato