University of Colorado

Other

Tsinghua University

Chang Gung University

Ding Xue

Jau-Song Yu

Man Zhang

Qian Liang

Yu Peng

Hanzeng Li

Jeng-Ting Chen

Xin Geng

Lingjun Zheng

Jay P Parrish

Xiaoyun Ding

Nakul Sridhar

Joyita Bhadra

A new on chip system, named Acoustic Gym, to apply a surface acoustic wave (SAW) has been developed to control the swimming exercise of a large number of small animals such asand Zebra fish, at desired intensities and durations. The SAW device consists of a circular chamber filled with fluid, which is placed in the center between a pair of offset interdigital transducers (IDTs) that are deposited on a piezoelectric substrate. Upon actuation from a radio frequency (RF) source, the SAW is generated and propagates along the substrate towards the microchamber. Once the SAW reaches the chamber, it induces an acoustic streaming in the fluid inside the chamber to stimulate swimming exercise of small animals. The streaming velocity can be precisely controlled via the RF signal input power, thus regulating the duration and intensity of exercise of the animals.

Gym on a chip for small animal exercise

The invention provides novel compositions and methods for the treatment of Radiation-Induced Bystander Effects (RIBE), resulting from radiation exposure. In one preferred embodiment the inventions includes novel therapeutic agents, including but not limited to quercetin and quercetin analogs, as well as E64, CA074, CA074Me, that interfere with the activity of Cathepsin B.

Compositions and methods for preventing and treating radiation-induced bystander effects caused by radiation or radiotherapy

The present invention provides compositions and methods for treating hepatitis B virus (HBV) infection as well as methods for identifying a compound or a composition that is suitable for treating HBV infection. In addition, the present invention provides a suitable non-mammalian animal model that can be used to screen for a compound or a composition that can inhibit HBV replication or treat HBV infection in a mammal. In particular, the present invention provides compositions and methods for treating hepatitis B infection by inhibiting interaction between HBV x protein and a Bcl-2 family protein or by reducing the expression level of a Bcl-2 family protein.

Compositions and methods for treating hepatitis B

An assay uses apoptotic nucleases to screen for apoptosis modulators, in a method of modulating apoptosis, and in a method of aiding in a diagnosis of a disease, among other methods. materials for use in the assay include isolated or recombinant polypeptides and polynucleotides, compositions comprising those isolated or recombinant polypeptides and polynucleotides, vectors, transgenic organisms, and integrated systems among other aspects.

Cell death-related nucleases and their uses

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Louisville, CO, United States of America

Ding Xue