Sphaera Pharma Pvt. Ltd.

Sphaera Pharma Pte. Ltd.

Inhibikase Therapeutics, Inc.

Epirium Bio Inc.

Drug Discovery Research Centre

Cardero Therapeutics, Inc.

Translational Health Science and Technology Institute

Dinesh Mahajan

Sundeep Dugar

George Frederic Schreiner

Frank Peter Hollinger

Rhushikesh Chandrabhan Deokar

Milton Henry Werner

Kamal Kishore Kapoor

Kanury Rao

Varshneya Singh

Kumar Santosh Rai

Ishwar Rakesh Patil

Vinayak Tripathi

Somdutta Sen

Bilash Kuila

Cyrus K Becker

Vijay Singh

Peter Giannousis Pantelis

Chandraban Rhushikesh Deokar

Amit Sharma

Frank Hollinger Peter

Sarbjit Singh

George Frederick Schreiner

Pantelis Peter Giannousis

The present invention relates to novel steroidal compounds of formula (I), process for preparation of the same and composition comprising these compounds. 

Hydroxysteroid compounds, their intermediates, process of preparation, composition and uses thereof

The present invention provides novel compounds with improved solubility and altered pharmacokinetic properties. The compounds of the present invention may be represented by Formula (I). 

Trigonelline based compounds

The present invention relates to novel compounds of formula (1):  The present invention also discloses compounds of formula (1) along with other pharmaceutical acceptable excipients and use of the compounds as anti-tubercular agents.

Compounds as anti-tubercular agents

The present invention relates to novel compounds of formula (1): The present invention also discloses compounds of formula (1) along with other pharmaceutical acceptable excipients and use of the compounds as anti-tubercular agents. 

The present invention provides novel analogs of epicatechin and related polyphenols, their variously functionalized derivatives, process for preparation of the same, composition comprising these compounds and their method of use.

Analogues of epicatechin and related polyphenols

Novel compounds and their synthesis are described. Methods for using these compounds in the prevention or treatment of cancer, a bacterial infection or a viral infection in a subject are also described.

Methods of treating tumoral diseases, or bacterial or viral infections

The present invention relates to novel triazine compounds of formula (1). The present invention also discloses compounds of formula I along with other pharmaceutical acceptable excipients and use of the compounds to modulate the PI3K/mTOR pathway.

Triazine compounds

A process for synthesis of enatiomerically pure or enatiomerically enriched or racemic mixture of (+ and/or &#x2212;) epicatechin and its intermediates, comprising the steps of: (i) obtaining penta-protected quercetin; (ii) reducing the penta-protected quercetin obtained from step (i); (iii) optionally deprotecting the compound of step (ii); (iv) reducing the compound obtained from step (ii) or step (iii) in the presence of a chiral/achiral reducing agent to obtain a chiral intermediate; (v) deprotecting and/or hydrogenation of the chiral intermediate obtained from step (iv) to obtain (&#x2212;)-epicatechin; (vi) optionally simultaneously deprotecting and by drogenation of the compound obtained from step (ii) to obtain racemic epicatechin.

Approach for synthesis of catechins

The present invention discloses novel chemical compounds obtained by causing a covalent attachment of a modifying agent of the structure provided for formula 1, to a functional group or a heteroatom of a heterocyclic ring system in chemical compound with improved chemical and biological properties. Wherein: Y is DRUG-CO; DRUG-OCO; DRUG-NRCO, and X is selected from.

Compounds, their synthesis and their uses

Compounds and compositions thereof

The present invention relates to novel triazine compounds of formula (1), methods of their preparation, pharmaceutical compositions containing these compounds and the use of these compounds to treat proliferative disorders such as tumors and cancers and also other conditions and disorders related to or associated with dysregulation of PI3 Kinases, PI3 Kinase pathway, mTOR and/or the mTOR pathway.

The present invention provides synthetic processes for preparing racemic and/or optically pure epicatechin, epigallocatechin and related polyphenols as such or as their variously functionalized derivatives. A principle objective of the disclosure is to provide a new and useful method of synthesis to obtain polyphenols in isomerically pure and/or racemic forms.

Process for synthesis of polyphenols

The present invention relates to the synthesis and application of novel chiral/achiral substituted methyl formyl reagents to modify pharmaceutical agents and/or biologically active substances to modify the physicochemical, biological and/or pharmacokinetic properties of the resulting compounds from the unmodified original agent.

Substituted methylformyl reagents and method of using same to modify physicochemical and/or pharmacokinetic properties of compounds

The present invention relates to compounds, compositions, and methods for treatment of conditions related to mitochondrial function. In various aspects, the present invention comprises administering one or more epicatechin derivatives in an amount effective to stimulate mitochondrial function in cells. The compounds, compositions, and methods described herein provide for reducing infarct size in the heart following permanent ischemia or ischemia/reperfusion event or method for delaying, attenuating or preventing adverse cardiac remodeling, and can assist in prevention of impaired mitochondria biogenesis and thus prevention of the consequences of impaired mitochondrial biogenesis in various diseases and conditions, as well as provide for the active therapy of mitochondrial depletion that may have already occurred.

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Haryana, India

Dinesh Mahajan