Ntc Technology, Inc.

Dinesh G Haryadi

Joseph Allen Orr

Michael Brian Jaffe

Kai K&uuml;ck

Kai Kuck

A method of non-invasively estimating the intrapulmonary shunt in a patient. The method includes non-invasively measuring respiratory flow, respiratory carbon dioxide content, and arterial blood oxygen content. A re-breathing process is employed to facilitate an estimate of the patient's pulmonary capillary blood flow. Any inaccuracies of the arterial blood oxygen content are corrected to provide a substantially accurate arterial blood oxygen content measurement. The respiratory flow, carbon dioxide content and arterial blood oxygen content measurements, and the pulmonary capillary blood flow estimate are employed to estimate an intrapulmonary shunt of the patient. The invention also includes a method of determining the total cardiac output of the patient which considers the estimated intrapulmonary shunt.

Methods of non-invasively estimating intrapulmonary shunt fraction and measuring cardiac output

Methods of measuring cardiac output using a non-invasively estimated intrapulmonary shunt fraction

A method of compensating for non-metabolic changes in respiratory or blood gas parameters including generating a compensatory signal based on the magnitude of the non-metabolic change and the amount of time elapsed since the onset of the non-metabolic change. The method of the present invention is useful for compensating for non-metabolic changes in non-invasive carbon dioxide elimination measurements and, particularly, when carbon dioxide elimination is employed to determine cardiac output on a non-invasive, continuous basis.

Method for compensating for non-metabolic changes in respiratory or blood gas profile parameters

A method of continuously, non-invasively determining the cardiac output of a patient. The method includes intermittently measuring the cardiac output, the volume of carbon dioxide exhaled by the patient per breath, and determining the arterial-venous gradient of the patient or a similar substantially constant value by dividing the volume of carbon dioxide exhaled by the measured cardiac output. The arterial-venous gradient or similar substantially constant value may then be employed to determine the cardiac output of the patient on a breath-by-breath basis. The carbon dioxide elimination, which is non-invasively measured as the volume of carbon dioxide exhaled by the patient per breath, is divided by the arterial-venous gradient or the substantially constant value to determine the cardiac output. The method may also include generating a signal to compensate for any non-metabolic changes in the carbon dioxide elimination, arterial-venous gradient, or other respiratory or blood gas profile measurements that may be caused by a change in ventilation or breathing of the patient. The compensatory signal may be employed to modify one or more of the respiratory or blood gas profile measurements in order to facilitate the accurate determination of cardiac output during or after changes in ventilation or breathing.

Method of continuously, non-invasively monitoring pulmonary capillary blood flow and cardiac output

A re-breathing method for determining pulmonary capillary blood flow that accounts for changes in the carbon dioxide content of a patient. The carbon dioxide elimination and partial pressure of end tidal carbon dioxide of the patient are measured prior to re-breathing, during re-breathing, and after re-breathing. A rate of change of carbon dioxide content of the venous blood of the patient is then calculated. The rate of change is then employed in calculating the pulmonary capillary blood flow of the patient.

Bi-directional partial re-breathing method

A method of calculating the carbon dioxide elimination of a patient that includes counteracting any inaccuracy or inconsistency in respiratory flow measurements that may be caused by 'noise', such as is attributable to respiratory circuit leaks, signal drift, a non-unity respiratory quotient, or another respiratory flow error-inducing factor. The method includes monitoring the respiratory flow and carbon dioxide of the patient during at least a portion of both inspiration and expiration; calculating an inspiratory tidal volume, an inspiratory volume averaged carbon dioxide fraction, an expiratory tidal volume, and an expiratory volume averaged carbon dioxide fraction; and selecting a tidal volume to replace at least one of the inspiratory tidal volume and the expiratory tidal volume. The carbon dioxide elimination of the patient is then calculated with the select tidal volume, the inspiratory volume averaged carbon dioxide fraction, and the expiratory volume averaged carbon dioxide fraction.

ISO-volumetric method of measuring carbon dioxide elimination

A method of non-invasively estimating the intrapulmonary shunt in a patient. The method includes non-invasively measuring respiratory flow, respiratory carbon dioxide content, and arterial blood oxygen content. A re-breathing process is employed to facilitate an estimate of the patient's pulmonary capillary blood flow. Any inaccuracies of the arterial blood oxygen content are corrected to provide a substantially accurate arterial blood oxygen content measurement. The respiratory flow and carbon dioxide content and arterial blood oxygen content measurements, and the pulmonary capillary blood flow estimate are employed to estimate an intrapulmonary shunt of the patient. The invention also includes a method of determining the total cardiac output of the patient which considers the estimated intrapulmonary shunt.

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Bengaluru, India

Dinesh G Haryadi