Genentech, Inc.

Biocon Limited

Dinesh Baskar

Inn Huam Yuk

Woon-Lam Susan Leung

Jenny Hsiung

Ramakrishnan Melarkode

Jose Enrique Montero Casimiro

Laxmi Adhikary

Pradip Nair

Saravanan Desan

Ankur Bhatnagar

Harish Venkatraman Pai

Sunaina Prabhu

Kriti Shukla

Rasika Venkataraman

An apparatus and method to maintain pH within a range conducive for cell growth in a bicarbonate-containing cell culture system without the addition of base. The method relies on the gas transfer characteristics of the bioreactor system to modulate the COtransfer to and from the cell culture such that the pH of the cell culture can be maintained within a desired range.

Method of culturing eukaryotic cells

The present invention relates to a method or process for controlling, inhibiting or reducing protein fucosylation in a eukaryote and/or eukaryotic protein expression system. Said method comprises carrying out the protein expression and/or post-translational modification in the presence of an elevated total concentration of manganese or manganese ions.

Methods for controlling fucosylation levels in proteins

The present invention relates to a method or process for controlling, inhibiting or reducing protein fucosylation in a eukaryote and/or a eukaryotic protein expression system. Said method comprises carrying out the protein expression and/or post-translational modification in the presence of an elevated total concentration of manganese or manganese ions.

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Bengaluru, India

Dinesh Baskar