Schering Corporation

Pharmacopeia Inc.

Adriano Afonso

John J. Baldwin

Ge Li

Randall R. Rossman

Dinanath F. Rane

Alan K. Mallams

John C. Reader

Ronald J. Doll

F. George Njoroge

Dinanath F Rane

Ronald J Doll

Alan K Mallams

F George Njoroge

Timothy J Guzi

Alan B Cooper

Viyyoor Moopil Girijavallabhan

Arthur G Taveras

Russell E Pike

Randall R Rossman

Joseph Michael Kelly

Jianping Chao

Jagdish A Desai

John J Baldwin

Carmen S Alvarez

Peter J Daniels

John J Wright

James J-s Wang

Ashit K Ganguly

Anil K Saksena

Corey Strickland

Joseph A Marquez

Gerald H Wagman

John C Reader

Tarik Lalwani

Cynthia J Aki

Johan A Ferreira

Bong K Lee

James Han Wang

Stacy W Remiszewski

Patrick A Pinto

Jay Weinstein

Kartik M Keertikar

Ray Anthony James

Edwin Jao

Chia-Yu Huang

Bancha Vibulbhan

Hugh Y Zhu

Keith P Minor

Bama Santhanam

Viyyoor M Ginjavallabhan

Jagdish J Desai

Disclosed are compounds of the formula: wherein Rrepresents a cyclic and acyclic moiety to which is bound an imidazolylalkyl group; Rrepresents a carbamate, urea, amide or sulfonamide group; and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.

Farnesyl protein transferase inhibitors and their use to treat cancer

Disclosed are novel tricyclic compounds represented by the formula (1.0): and a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising compounds of formula 1.0. Also disclosed are methods of treating cancer using the compounds of formula 1.0.

Farnesyl protein transferase inhibitors as antitumor agents

Farnesyl protein transferase inhibitors

Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases

Novel compounds of the formula: ##STR1## wherein a represents N or NO, R.sup.1 and R.sup.3 are halo, R.sup.2 and R.sup.4 are independently H or halo provided that at least one is H, X is C, CH or N, and T represents ##STR2## wherein R.sub.5 is H (C.sub.1 -C.sub.6)alkyl or a bond; b and c are independently 0 to 3 and Y is a three, four, five or six membered cycloalkyl ring, pyridyl, pyrazinyl or phenyl are disclosed. Pharmaceutical Compositions containing such compounds, methods of inhibiting farnesyl protein transferase and methods for treating tumor cells using such compounds or compositions are also disclosed.

Novel tricyclic compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel tricyclic compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.

Tricyclic compounds useful as inhibitors of farnesyl-protein transferase

Compounds the formula ##STR1## their use as farnesyl transferase protein inhibitors and pharmaceutical compositions containing them are disclosed, especially compounds of the formula ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are halo, A and B are each H.sub.2, and R is as defined in the specification.

Tricyclic compounds useful for inhibition of G-protein function and for

Compounds of the following formula useful for inhibiting Ras function and therefore inhibiting or treating the abnormal growth of cells are disclosed: ##STR1## or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof, wherein:

Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein

Novel compounds of Formula ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the formula to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.

Tricyclic compounds

Novel compounds of Formula ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the above formula to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.

Compounds of the formula ##STR1## or pharmaceutically acceptable salts thereof wherein R.sub.1, R.sub.2, X.sub.1, X.sub.2, X.sub.3, X.sub.4, X.sub.5, X.sub.6, X.sub.7, and X.sub.8, are as set forth herein are described. These compounds are useful as agents in the treatment of fungal infections.

Anti-fungal agents

Growing community of inventors

Morganville, NJ, United States of America

Dinanath F Rane