Biogen Idec Ma Inc.

Yale University

Nsgene A/s

Dinah W Y Sah

Teit E Johansen

Stephen M Strittmatter

Anthony Rossomando

R Blake Pepinsky

Richard L Cate

Daniel H S Lee

Jane K Relton

Dane S Worley

Sylvia A Rabacchi

Weiwei Li

The invention relates to neublastin neurotrophic factor polypeptides, nucleic acids encoding neublastin polypeptides, and antibodies that bind specifically to neublastin polypeptides, as well as methods of making and methods of using the same.

Neurotrophic factors and methods of use thereof

Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same.

Nogo receptor antagonists

Methods of activating RET receptor tyrosine kinase using neurotrophic factors

The invention relates generally to genes that encode proteins that inhibit axonal growth. The invention relates specifically to genes encoding NgR protein homologs in humans and mice. The invention also includes compositions and methods for modulating the expression and activity of Nogo and the NgR proteins. Specifically, the invention includes peptides, proteins and antibodies that block Nogo-mediated inhibition of axonal extension. The compositions and methods of the invention are useful in the treatment of cranial or cerebral trauma, spinal cord injury, stroke or a demyelinating disease.

Nogo receptor homologs that decrease inhibition of axonal elongation

Methods of treating pain using neurotrophic factors

Neurotrophic factors

Nogo receptor homologs

Growing community of inventors

Boston, MA, United States of America

Dinah W Y Sah