Waters Technologies Corporation

Dimple Shah

Matthew A Lauber

Theodore A Dourdeville

Jonathan L Belanger

Jacob Nathan Fairchild

Mathew H DeLano

Nicole L Lawrence

Kerri M Smith

Stephen J Shiner

Michael Donegan

Scott A McCall

Catalin Doneanu

Paul Rainville

Babajide Okandeji

A device for separating analytes is disclosed. The device has a sample injector, sample injection needle, sample reservoir container in communication with the sample injector, chromatography column downstream of the sample injector, and fluid conduits connecting the sample injector and the column. The interior surfaces of the fluid conduits, sample injector, sample reservoir container, and column form a flow path having wetted surfaces. A portion of the wetted surfaces of the flow path are coated with an alkylsilyl coating that is inert to at least one of the analytes. The alkylsilyl coating has the Formula I: R, R, R, R, R, and Rare each independently selected from (C-C)alkoxy, —NH(C-C)alkyl, —N((C-C)alkyl), OH, OR, and halo. Rrepresents a point of attachment to the interior surfaces of the fluidic system. At least one of R, R, R, R, R, and Ris OR. X is (C-C)alkyl, —O[(CH)O]—, —(C-C)[NH(CO)NH(C-C)]—, or —(C-C)[alkylphenyl(C-C)alkyl]-.

Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes

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Medway, MA, United States of America

Dimple Shah