Transonic Systems, Inc.

Dimitry M Starostin

Nikolai M Krivitski

An apparatus is provided for determining a calibration coefficient of a blood property sensor located in a blood system, wherein the blood system can include a vascular portion and an extracorporeal portion. The blood property sensor can be located in the extracorporeal portion to measure the change in a blood property corresponding to the passing of an indicator. The indicator can include a known amount of an introduced dilution indicator. The controller is provided for determining the calibration coefficient of the blood property sensor corresponding to the introduced dilution indicator in the measured change in the blood property.

Blood volume determination and sensor calibration

A method and device for the continuous real-time monitoring of relative blood volume change, based on registration of blood hemoglobin concentration, during long periods of time, such as dialysis session. A method and device for cardiac output measurement during dialysis, surgeries, intensive care procedure is provided. Calibration of a sensor in response to a change in a measureable blood property is determined from a coefficient corresponding to a change in the measured blood property.

Sensor calibration and blood volume determination

A method and device for the continuous real-time monitoring of relative blood volume change, based on registration of blood hemoglobin concentration, during long periods of time, such as dialysis session. A method and device for cardiac output measurement, based on optical dilution technique, during dialysis, surgeries, intensive care procedure. The effects of blood electrolyte composition change which result in a change of light beam geometry are eliminated by the relative orientation between a light source and a single light or photodetector. An illumination axis and a detection axis are oriented in an offset, non collinear configuration at a sufficient angle to substantially eliminate the scattering properties of the blood. A primary implementation of the device is extracorporeal paths, such as hemodialysis tubing systems, artery-vein extracorporeal artificial shunts, other extracorporeal systems. It also may be applied to vessels, tissues or to body parts being capable of transillumination.

Single light sensor optical probe for monitoring blood parameters and cardiovascular measurements

A method and device for the continuous real-time monitoring of relative blood volume change, based on registration of blood hemoglobin concentration, during long periods of time, such as dialysis session. A method and device for cardiac output measurement, based on optical dilution technique, during dialysis, surgeries, intensive care procedure. The effects of blood electrolyte composition change which result in a change of light beam geometry are eliminated by the relative orientation between a light source and a single light or photodetector. An illumination axis and a detection axis are oriented in an offset, non colinear configuration at a sufficient angle to substantially eliminate the scattering properties of the blood. A primary implementation of the device is extracorporeal paths, such as hemodialysis tubing systems, artery-vein extracorporeal artificial shunts, other extracorporeal systems. It also may be applied to vessels, tissues or to body parts being capable of transillumination.

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Ithaca, NY, United States of America

Dimitry M Starostin