Louisiana State University and Agricultural & Mechanical College

Cornell University

The University of North Carolina at Chapel Hill

Northeastern University

Dimitris Nikitopoulos

Michael C Murphy

Francis Barany

Steven A Soper

Robin L McCarley

Collin J McKinney

Sunggook Park

Elizabeth J Podlaha-Murphy

George Grills

Dorel Moldovan

Daniel Sang-won Park

Taehyun Park

Sudheer D Rani

The present invention relates to a device comprising a biomolecular processor. Each biomolecular processor has one or more bioreactor chambers defined by a solid substrate; a support structure within each bioreactor; a cleaving enzyme immobilized to the support structure and operatively positioned within the bioreactor chamber to cleave monomer or multimer units of a biopolymer molecule operatively engaged by the cleaving enzyme; and one or more time-of-flight channels formed in the solid substrate and fluidically coupled to said one or more bioreactor chambers. Each of the time-of-flight channels have two or more sensors including at least (i) a first sensor contacting the time-of-flight channel proximate to the input end of the channel and (ii) a second sensor contacting the time-of-flight channel proximate to the output end of channel. The present invention further relates to methods of sequencing and identifying biopolymer molecules using the device.

Biomolecular processing platform and uses thereof

A device and methods are provided for efficient and quick capture of target cells through a main microchannel having capture elements immobilized thereon and manipulating a velocity profile of a sample as it passes through the main microchannel. The cell capture device may have a main microchannel with a depth slightly larger than the diameter of the target cells and a plurality of side microchannels. The side microchannels may have a depth smaller than the diameter of the target cells. The device and methods may be used for early cancer detection.

Methods of and devices for capturing circulating tumor cells

Growing community of inventors

Baton Rouge, LA, United States of America

Dimitris Nikitopoulos