Nokia Corporation

Bionevia Pharmaceuticals, Inc.

Bionevia, LLC

Nokia Technologies Oy

Dimitris Kalofonos

Jeffrey S Stults

Travis Lee Houston

G Patrick Stahly

Isabel Kalofonos

William Martin-Doyle

Zoe Antoniou

Franklin Reynolds

Vlad Alexandru Stirbu

Mark Peterson

Mika Saaranen

Eric Anthony Silva

James Card

Saad Shakhshir

Parijat Shah

Hans Peter Brondmo

Eric Cheng

Jacob Barss-Bailey

Cathy Chan

Vlad Stirbu

The invention relates to a novel choline cocrystal of 5-[(1Z.2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid. The preparation and characterization of the novel choline cocrystal according to various embodiments of the invention is described. The invention also relates to pharmaceutical compositions containing the novel choline cocrystal and the therapeutic use of the novel choline cocrystal to treat and/or prevent various conditions, including treating and/or preventing diabetic complications, treating and/or preventing homocystinuria reducing levels of homocysteine in blood serum, inhibiting aldose reductase, and affording cardioprotection in non-diabetic patients.

Choline cocrystal of epalrestat

The invention relates to a novel choline cocrystal of 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid. The preparation and characterization of the novel choline cocrystal according to various embodiments of the invention is described. The invention also relates to pharmaceutical compositions containing the novel choline cocrystal and the therapeutic use of the novel choline cocrystal to treat and/or prevent various conditions, including treating and/or preventing diabetic complications, treating and/or preventing homocystinuria reducing levels of homocysteine in blood serum, inhibiting aldose reductase, and affording cardioprotection in non-diabetic patients.

The invention relates to novel crystalline salts of 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid and a novel betaine cocrystal of 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid. The preparation and characterization of the novel crystalline salts and cocrystal according to various embodiments of the invention is described. The invention also relates to pharmaceutical compositions containing the novel crystalline salts and cocrystal and the therapeutic use of the novel crystalline salts and cocrystal to treat and/or prevent various conditions, including treating and/or preventing diabetic complications, inhibiting aldose reductase, and affording cardioprotection in patients who may be non-diabetic.

Solid forms of epalrestat

Management of access control in wireless networks known as smart spaces includes a framework that presents non-expert users with a consistent and intuitive interaction mechanism to manage access to devices they own in the smart space without exposing to them the complexity of the underlying security infrastructure. Access control of devices in a network can include providing an interface between a user-level tool on a first device connected to a network and security components associated with the network, communicating a passlet between the user-level tool and the interface, verifying access permission at a second device on the network where access permissions are based on the passlet, and providing a response to the first device based on the verification of the access permission in the passlet. The passlet provides access permissions based on a particular user rather than a particular device.

Management of access control in wireless networks

An approach for generating location stamps in response to a request from a device is presented. A location stamping platform receives a request from a device for one or more location stamps. The location stamping platform then processes and/or facilitates a processing of a hierarchy of one or more policies to determine one or more candidate location stamps in response to the request.

Method and apparatus for generating location stamps

Secure resource discover in peer-to-peer networks involves creating a resource discovery record associated with a computing resource of a user device that is made available via the user device to peers of a peer-to-peer network. The resource discovery record describes the computing resource and may be independent of native service discovery mechanisms of the peer-to-peer network. An access right record is created that controls the ability of one or more contacts to gain access to the resource discovery record. The resource discovery record is sent to the one or more contacts via the peer-to-peer network. The one or more contacts can use the resource discovery record to access the computing resource via the peer-to-peer network in accordance with the access right record.

Access rights used for resource discovery in peer-to-peer networks

An apparatus is provided that includes a processor configured to receive a captured traffic unit (CTU) intended for a network service, the CTU being one into which incoming traffic has been assembled based on a filter describing which incoming traffic to capture and how to assemble the respective incoming traffic into the CTU. The processor is also configured to determine whether to allow the CTU to pass to one or more applications configured to implement the respective network service based on a passlet including permissions to a particular user. The processor is further configured to instruct a firewall to allow the CTU to pass to the respective one or more applications or to reject the CTU based on the determination. In this regard, the processor is configured to perform the above functions under control of a security framework implemented in middleware between a user-level domain and a system-level domain.

Apparatus and method for managing access to one or more network resources

A mobile terminal includes a processor capable of operating a link manager. The link manager is capable of at least partially operating a wireless connection between the terminal and an access point in an active mode, where the access point is coupled to a network. The link manager is also capable of transitioning the connection from the active mode to a standby mode or hibernate mode. In this regard, transitioning the connection includes entering the mobile terminal in a power-saving mode of a bearer of the connection, such as a Bluetooth power-saving mode, and directing the access point to reduce traffic flowing from the network across the connection to the mobile terminal when the mobile terminal is otherwise capable of receiving the traffic.

System and method for managing a wireless connection to reduce power consumption of a mobile terminal

Provided are improved systems, nodes, and methods for enabling dynamic end-to-end (e2e) session-enhancing services for transport-level connections such as TCP-based connection sessions, thereby providing the communicating entities the ability to select, adjust, and control e2e session enhancing (e2e-SE) services before and during communications. Embodiments allow for dynamic negotiation and renegotiation of e2e session-enhancing services at establishment of and during the active course of communication sessions, such as at establishment of and during transparent e2e-SE services TCP connections. Embodiments may be used as part of any e2e session-enhancing services framework for mobile or wireless and wireline communications. End-to-end session-enhancing services can be dynamically added and removed according to the need of applications and existing and changing conditions without affecting the on-going communication and the applications running on both end nodes.

Growing community of inventors

Cambridge, MA, United States of America

Dimitris Kalofonos