American Home Products Corporation

Other

Wyeth

Elan Pharmaceuticals, Inc.

Dimitrios Sarantakis

Eugene D Thorsett

Michael A Pleiss

Susan Ashwell

Andrei William Konradi

Christopher Michael Semko

Francine S Grant

Anthony Frank Kreft

Darren B Dressen

Gregory Scott Welmaker

Ying-Zi Xu

Reinhardt Bernhard Baudy

Louis John Lombardo

Michael S Dappen

Norman H Grant

Cynthia Y Robinson

Christopher Joseph Soares

Kiev S Ly

Christine M Tarby

Frank Stappenbeck

Eric L Lien

Francine S Farouz

William Dvonch

Robert Warren Sullivan

Larry Stein

Michael A Pliess

Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

Heteroaryl, heterocyclic and aryl compounds which inhibit leukocyte adhesion mediated by VLA-4

Disclosed are certain alpha amino acid compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

Alpha amino acid derivatives-inhibitors of leukocyte adhesion mediated by VLA-4

Carbamyloxy compounds which inhibit leukocyte adhesion mediated by VLA-4

Disclosed are a series of phenylalanine derivatives, to compositions containing them, to processes for their preparation, and to their use in medicine.

Phenylalanine derivatives as alpha 4 integrin inhibitors

Beta-amino acid derivatives-inhibitors of leukocyte adhesion mediated by VLA-4

Compounds which inhibit leukocyte adhesion mediated by VLA-4

Disclosed are a series of heteroaryl-&#x3b2;-alanine derivatives, compositions containing them, processes for their preparation and their use in medicine.

Heteroaryl-&#x3b2;-alanine derivatives as alpha 4 integrin inhibitors

Alpha amino acid derivatives&mdash;inhibitors of leukocyte adhesion mediated by VLA-4

Disclosed are certain 3-(heteroaryl)alanine derivatives which bind VLA-4 and inhibit leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

3-(heteroaryl) alanine derivatives-inhibitors of leukocyte adhesion mediated by VLA-4

Growing community of inventors

West Chester, PA, United States of America

Dimitrios Sarantakis