The Brigham and Women's Hospital, Inc.

Children's Medical Center Corporation

Dimitrios Mitsouras

Robert V Mulkern

Frank John Rybicki

The present invention provides a method for producing density-compensated MR images having improved signal-to-noise ratio and with reduced computational burden. The method includes sampling MR data using a rotationally symmetric acquisition trajectory, generating a cross-correlation matrix, and applying a discreet Fourier transform (DFT) to the acquired MR data and the cross correlation matrix. The method further includes employing the transformed MR data and transformed cross-correlation matrix in a linear system to produce a set of density-compensated transformed MR data, which may transformed into density compensated MR data by application of an inverse DFT. The density compensated MR data may be reconstructed by a variety of techniques to produce density compensated images.

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Brookline, MA, United States of America

Dimitrios Mitsouras