Ge Healthcare Limited

Bayer As

Dimitrios Mantzilas

Torgrim Engell

Julian Grigg

Steven Michael Fairway

Eric Horn

Dag M Evje

Jan Roger Karlson

Nigel Anthony Powell

Judit Tjelmeland Østby

Harry John Wadsworth

William John Trigg

Imtiaz Ahmed Khan

Radha Achanath

Dennis O'Shea

Torild Wickstrom

Sondre Nilsen

Bo Shan

Joanna Marie Passmore

Umamaheshwar P Mokkapati

Janne Olsen Frenvik

Srinath Balaji

Afsal Mohammed Kadavilpparampu Mohamed

Gry Helene Olaussen

Judit Tjelmeland Ostby

Umamaheshwar Mokkapati

A method for removing or controlling or quantifying the presence of aldehydes, in particular acetaldehyde, is described. Such a method is useful in prolonging the shelf life of a pharmaceutical product.

Method for removing acetaldehyde

The present invention comprises a method for the generation ofTh of pharmaceutically tolerable purity comprising Purified thorium-227 of pharmaceutical purity and a pharmaceutical composition comprising the same are also provided.

Isotope preparation method

The present invention provides a method for the purification ofTh from a mixture comprisingTh andRa, said method comprising: i) preparing a first solution comprising a mixture ofTh andRa ions dissolved in an aqueous solution of first mineral acid; ii) loading said first solution onto a strong base anion exchange resin; iii) elutingRa from said strong base anion exchange resin using a second mineral acid in an aqueous solution; iv) optionally rinsing said strong base anion exchange resin using a first aqueous medium; v) elutingTh from said strong base anion exchange resin using a third mineral acid in an aqueous solution whereby to generate a second solution comprisingTh. The invention further provides a purifiedTh solution, a corresponding pharmaceutical formulation and methods of treatment of neoplastic disease.

The present invention relates to improved radiotracer imaging agent compositions, which comprisesF-labelled biological targeting moieties, wherein impurities which affect imaging in vivo are identified and suppressed. Also provided are radiopharmaceuticals comprising said improved compositions, together with radiofluorinated aldehyde compositions useful in preparing said radiotracer compositions. The invention also includes methods of imaging and/or diagnosis using the radiopharmaceutical compositions described.

Radiotracer compositions

A method for the purification of cyclic indole compounds that provides advantages over previously-known methods. Using the method of the present invention allows for the facile preparation of a good quality solid form of these compounds.

Enantiomeric separation and purification of 2,3,4,9-tetrahydro-1H-carbazole-4-carboxylic acid amide derivatives

A diagnostic imaging agent useful for positron emission tomography (PET) imaging as well as to improved hardware for producing such imaging agents is described. Flutemetamol (F) Injection for the imaging of &#x3b2;-amyloid plaques in the brain and methods and devices for preparing same are described including the automated synthesis and purification of [F]flutemetamol by means of solid phase extraction (SPE).

Purification method

The present invention provides a method to prepare anF-labelled tricyclic indole compound comprising a solid-phase extraction (SPE) purification step. This method is particularly suitable for carrying out the radiofluorination method on an automated synthesizer. In addition to the radiofluorination method, the present invention provides a cassette designed to carry out the method on an automated synthesizer.

Solid phase extraction method

A diagnostic imaging agent useful for positron emission tomography (PET) imaging as well as to improved hardware for producing such imaging agents is described. Flutemetamol (18F) Injection for the imaging of b amyloid plaques in the brain and methods and devices for preparing same are described including the automated synthesis and purification of [18F]flutemetamol by means of solid phase extraction (SPE).

The present invention provides a PET tracer that has improved properties for imaging the peripheral benzodiazepine receptor (PBR) as compared with known such PET tracers. The present invention also provides a precursor compound useful in the preparation of the PET tracer of the invention and methods for the preparation of said precursor compound and said PET tracer. Also provided by the present invention is a radiopharmaceutical composition comprising the PET tracer of the invention. Methods for using the PET tracer and the radiopharmaceutical composition are also provided.

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Oslo, Norway

Dimitrios Mantzilas