University of California

Dana-farber-cancer Institute Inc.

Children's Medical Center Corporation

Athos Therapeutics, Inc.

Attica Sciences Ltd.

Dimitrios Iliopoulos

Richard Gregory

Elena Piskounova

Michael E Jung

David G Ho

Charalabos Pothoulakis

Dimitra Chalkia

Jonghoon Kim

Ka Man Law

Iordanes Karagiannides

Iordanis Karagiannidis

Jill M Hoffman

Phithi Nguyen

Analogues of oleuropein and oleacein and pharmaceutically acceptable salts thereof and processes for the preparation of these compounds are disclosed. The invention further relates to use of oleuropein and oleacein analogues for the treatment of inflammatory disorders, cardiometabolic disorders, and cancer.

Analogues of oleuropein and oleacein and uses thereof

The present disclosure provides compounds and compositions capable of treating cancer or an autoimmune disease, such as Crohn's disease, and methods of use thereof.

Compositions and methods for treating epigenetic disease

Disclosed herein are quinazolinyl compounds, compositions, and methods of use thereof. The compounds may be used in the treatment of autoimmune disorders or cancer.

Small molecules for the treatment of autoimmune diseases and cancer

The present embodiments provide for compositions and methods that regulate microRNA-binding protein-mediated miRNA biogensis; for example Lin28-mediated biogenesis of let-7; and in particular Lin28A-recruited 3' terminal uridylyl transferase (TUTase) uridylation of pre-let-7. A particular embodiment provide compositions and methods for screening for agents that inhibit TUTase-dependent Lin28A-mediated repression of let-7 miRNA.

Lin28-mediated control of let-7 biogenesis

This application discloses methods of treating, preventing, and diagnosing colorectal cancer and IBD in a subject comprising administering an effective dose of antisense miR-133&#x3b1; or AFTPH to the subject or detecting expression levels of miR-133&#x3b1; and AFTPH.

Neurotensin-induced tumor formation is regulated by micro RNA 133A-aftiphilin-dependent receptor recycling

The present embodiments provide for compositions and methods that regulate microRNA-binding protein-mediated miRNA biogenesis; for example Lin28-mediated biogenesis of let-7; and in particular Lin28A-recruited 3' terminal uridylyl transferase (TUTase) uridylation of pre-let-7. A particular embodiment provide compositions and methods for screening for agents that inhibit TUTase-dependent Lin28A-mediated repression of let-7 miRNA.

Growing community of inventors

Los Angeles, CA, United States of America

Dimitrios Iliopoulos