Boehringer Ingelheim International Gmbh

Orexo Ab

Dimitrijs Lubriks

Dirk Stenkamp

Henning Priepke

Roland Pfau

Benjamin Pelcman

Raimund Kuelzer

Edgars Suna

Robert Roenn

Henri Doods

Juergen Mack

Kirsten Arndt

Klaus Klinder

The present invention relates to compounds of general formula I in which A, L, M, Q, Q, Q, R, R, R, R, R, W, X, Y, Z, Z, Zare defined in the description, the salts thereof, particularly the physiologically acceptable salts thereof. The compounds are of potential utility in the treatment and/or prevention of inflammatory diseases and associated conditions, in particular, in the treatment and/or prevention of pain. The invention also relates to the use of such compounds as medicaments, to pharmaceutical compositions containing them, and to their preparation.

Compounds

This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin Esynthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R, R, R, Rhave meanings given in the description.

Inhibitors of the microsomal prostaglandin E2 synthase-1

This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin Esynthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, L, M, W, R, R, R, R, R, R, R, Rhave meanings given in the description.

This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin Esynthase-1 (mPGES-1), to pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R, R, R, R, R, R, R, R, R, R, Rhave meanings given in the description.

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Riga, Latvia

Dimitrijs Lubriks