Massachusetts Eye and Ear Infirmary

Verily Life Sciences LLC

Twenty Twenty Therapeutics LLC

The General Hospital Corporation

University of Illinois

Dimitri T Azar

Supriyo Sinha

Joshua N Haddock

Shungneng Lee

Damien Gatinel

Jacques Malet

Daniel B Otts

Timothy D Stowe

Patricia Johnson

Jeremy L Emken

Sohyun Park

Anil Kumar Ram Rakhyani

Brooke C Basinger

Jin-Hong Chang

Fred Shungneng Lee

Sam Kavusi

Eden Rephaeli

Todd Whitehurst

Stein Kuiper

Michael R Allen

Robert W Redmond

Irene Emily Kochevar

Sandeep Jain

James Polans

Kirk Gossage

Jose De La Cruz

Elena Albé

Prachi Shah

Patricia E Johnson

An intraocular micro-display (IOMD) implant includes an enclosure shaped for implantation into an eye, a micro-display, a base lens, and an adjustable lens. The micro-display is disposed in the enclosure and oriented to emit an image towards a retina of the eye. The base lens has a fixed optical power, is attached to the enclosure, and is positioned relative to the micro-display to reside in an optical path extending between the micro-display and the retina. The base lens is configured to apply the fixed optical power to the image. The adjustable lens is disposed in the optical path between the micro-display and the retina. The adjustable lens has an adjustable optical power that is adjustable in-situ to adjust a focal distance of the image projected by the IOMD implant after the IOMD implant has been implanted into the eye.

Adjustable optical system for intraocular micro-display

An intraocular system that includes a headset that optically transmits data and power to an implant. The headset includes a camera to capture image data that includes a visual representation of an environment of the headset and an optical transmitter to transmit the image data as an optical signal into a cornea of an eye of a user when the user is wearing the headset. The implant includes an optical receiver to receive the optical signal through the cornea and an image formation device orientated to present the image data from the optical signal onto a retina of the eye when the implant is inside the eye.

Intraocular system for transmitting data and power optically to an implant

An intraocular micro-display (IOMD) system includes an auxiliary head unit. The auxiliary head unit includes a frame for mounting to a head of a user, a scene camera module mounted in or on the frame in a forward-facing orientation, a gaze tracking module disposed in or on the frame and configured to monitor an eye of the user, and an auxiliary controller. The auxiliary controller includes for: acquiring a scene image with the scene camera module, determining a gazing direction of the eye based upon gaze direction data from the gaze tracking module, identifying a sub-portion of the scene image based upon the gazing direction, and wirelessly relaying the sub-portion of the scene image to an IOMD implant within the eye for displaying to a retina of the eye.

Natural physio-optical user interface for intraocular microdisplay

In some aspects, an electronic contact lens for treating dry eye is presented. According to some aspects, the electronic contact lens includes a concave surface configured to conform to an eye of a patient, a sensor configured to generate a signal indicative of an eyelid movement, and at least one capacitor configured to store energy used for stimulating the eye. The electronic contact lens may further include at least two electrodes coupled to the at least one capacitor, wherein the at least two electrodes are exposed to the concave surface and configured to deliver power from the at least one capacitor to stimulate the eye. The electronic contact lens further includes a processor coupled to the sensor and electrodes. The processor may be configured to compute a blink rate from the sensor output, and, based on the blink rate, activate the at least two electrodes to stimulate the eye.

Ophthalmic devices, systems and methods for treating dry eye

An intraocular micro-display system includes an intraocular micro-display (IOMD) implant and an auxiliary head unit for delivering power and image data to the IOMD implant. The IOMD implant includes an enclosure shaped for implantation into an eye, a micro-display to emit images towards a retina, an energy storage unit to power the micro-display, a charging antenna for wireless charging of the energy storage unit via a power signal incident upon the first charging antenna, and a data antenna to wirelessly receive the image data for driving the micro-display to emit the images. The charging antenna and the data antenna are implantable into the eye with the IOMD implant.

Intraocular micro-display system with intelligent wireless power delivery

Endoscopic systems including multimode optical fibers for and methods of interrogating a portion of a body are described. In an example, the endoscopic system includes a multimode optical fiber, a coherent light source positioned to emit coherent light through the multimode optical fiber, and a photodetector positioned to absorb scattered coherent light emitted from the multimode optical fiber and configured to generate a speckled light signal based on the scattered coherent light. In an example, the endoscopic system includes a controller configured to analyze the speckled light signal with machine learning classifier and to generate an identification signal indicative of a characteristic of the portion of the body.

Endoscopic systems including a multimode optical fiber and a machine learning classifier for interrogating a portion of a body

Disclosed is a headset for monitoring periocular humidity, the headset including a housing configured to be positioned on a user's face and defining a periocular air space. The headset includes a humidity sensor configured to measure a humidity of air within the periocular air space, and an ophthalmic testing unit configured to measure a physiological parameter of an eye of the user. The headset further includes a processor coupled to the humidity sensor and the ophthalmic testing unit. The processor is configured to receive the measured humidity and the measured physiological parameter, and determine an ophthalmic condition based on the measured humidity and the measured physiological parameter.

Periocular environment monitoring in a headset

Systems, devices and methods that facilitate safe heating of eyelids to treat dry eye are disclosed. According to one embodiment, an apparatus for optical heating of an eyelid of a patient includes: a housing configured to be grasped by a human hand; at least one light emitter coupled to the housing and configured to emit beams of infrared light; a waveguide component coupled to the at least one light emitter and configured to direct the beams of light toward the eyelid; and a scleral cover configured to couple to the housing, the scleral cover comprising: a curved protective portion configured to reflect infrared light emanating from the at least one light emitter.

Gland treatment devices and methods for treating dry eye disease

A device is presented herein that is configured to be located underneath an eyelid and worn by a user for treating dry eye. The device includes a first surface configured to face a portion of a sclera of the eye, and a second surface configured to face an eyelid and to be completely covered by the eyelid. In some embodiments, the device further includes a plurality of stimulation electrodes proximal to the first surface, wherein the plurality of stimulation electrodes is configured to stimulate the sclera. The device further includes an energy storage element coupled to the plurality of stimulation electrodes. The energy storage element is configured to supply power to the plurality of stimulation electrodes. The device further includes a processor configured to control a supply of energy from the energy storage element to the plurality of stimulation electrodes to stimulate the sclera.

Therapeutic devices for placement underneath the eyelid and associated systems, devices, and methods for dry eye treatment

Devices, systems, and associated methods for detecting drops dispensed by a dropper are provided. For example, a drop detection device may include a light source and a light detector configured to be coupled to a drop dispenser such that the light source and light detector are disposed proximal of a distal dispensing tip of the drop dispenser. The light detector may be configured to receive a reflected portion of a beam of light from the light source, which is reflected by a drop dispensed through the dispensing tip of the drop dispenser. In some embodiments, a processing circuit is configured to analyze a signal provided by the light detector to detect the dispensed drop.

Detecting backscatter from drops dispensed from a handheld dropper and associated systems, devices, and methods

According to some aspects, a device is presented herein that is configured to be located underneath an eyelid and worn by a user for treating dry eye. The device includes a first surface configured to face a portion of a sclera of the eye, and a second surface configured to face an eyelid and to be completely covered by the eyelid. In some embodiments, the device further includes a plurality of stimulation electrodes proximal to the first surface, wherein the plurality of stimulation electrodes is configured to stimulate the sclera. The device further includes an energy storage element coupled to the plurality of stimulation electrodes. The energy storage element is configured to supply power to the plurality of stimulation electrodes. The device further includes a processor configured to control a supply of energy from the energy storage element to the plurality of stimulation electrodes to stimulate the sclera.

Techniques and mechanisms for the wireless transmission of power or control signals between two components of an implantable ophthalmic system are disclosed herein. An example device includes an accommodating intraocular lens (aIOL) and separate auxiliary electronics, both enclosed in biocompatible materials. The aIOL includes a dynamic optic, control logic, a battery and an antenna. The auxiliary electronics include an antenna, an energy storage cell, and a sensor. The auxiliary electronics may be wirelessly coupled to the aIOL for the wireless transmission of power or control signals.

Intraocular device with wirelessly coupled auxiliary electronics

Adjustable ophthalmic devices, systems including adjustable ophthalmic devices, and methods of adjusting an optical power of an ophthalmic device are described. In an embodiment, the ophthalmic devices include a body including an inner surface defining an aperture through the body, wherein the inner surface includes a feature selected from a sharp surface feature, a layer on at least a portion of the inner surface having a surface energy different than a surface energy of the inner surface, and a combination thereof. In an embodiment, the ophthalmic device includes two immiscible liquids disposed in the aperture defining a meniscus, wherein a curvature of the meniscus is defined at least in part by a position of an interface between the layer and the inner surface, a position of the sharp surface feature, or combination thereof.

Growing community of inventors

Brookline, MA, United States of America

Dimitri T Azar