Bristol-myers Squibb Compnay

Dimitri Skliar

Michael J Smith

Richard J Fox

Junying Fan

Peng Geng

Carlos A Guerrero

Neil A Strotman

Michael Dummeldinger

Candice Lee Joe

Alina Borovika

Harshkumar Patel

David Thomas George

Yichen Tan

Jason Michael Stevens

Shane Mckenna

Improved methods and intermediates thereof for preparing carbamoyloxy methyl triazole cyclohexyl acid compounds are described. These compounds are useful as LPA antagonists. Formula (I).

Process for preparing carbamoyloxymethyl triazole cyclohexyl acid compounds

Disclosed is a process for preparing (S)-4-(3-(but-2-ynamido)piperidin fluoro-2,3-dimethyl-1H-indole-7-carboxamide, comprising the steps of: preparing a compound of Formula (III); converting the compound of Formula (III) to a compound of Formula (V); and reacting the compound of Formula (V) with a compound of Formula (VI) to provide (S)-4-(3-(but-2-ynamido)piperidin-1-yl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide. 

Process for preparing indole carboxamide compounds

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Staten Island, NY, United States of America

Dimitri Skliar