University of Florida Research Foundation, Incorporated

Stc.unm

Dimitri Dascier

David G Whitten

Kirk S Schanze

Thomas S Corbitt

Anand Parthasarathy

Eunkyung Ji

Linnea K Ista

Eric H Hill

Ying Wang

Motokatsu Ogawa

Kirsten Nicole Cicotte

Elizabeth LeBleu Dirk

Xuzhi Zhu

Zhijun Zhou

Yanli Tang

Subhadip Goswami

The present disclosure provides novel poly(phenylene ethynylene) (PPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various PPEs show antibacterial, antiviral and antifungal activity.

Structure, synthesis, and applications for poly (phenylene) ethynylenes (PPEs)

The present disclosure provides novel oligo phenylene ethynylene (OPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various OPEs show antibacterial, antiviral and antifungal activity.

Structure, synthesis, and applications for oligo phenylene ethynylenes (OPEs)

The invention provides methods and materials for decontamination of surfaces and fabrics, such as non-woven fabrics, that are contaminated with infestations of microorganisms such as bacteria. Biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group can be used to decontaminate infested surfaces in the presence of oxygen and, optionally, illumination. Fibers incorporating biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group, wherein the oligomer is physically associated with or covalently bonded to, or both, the fiber-forming polymer can be used to form non-woven mats. Biocidal non-woven mats prepared by methods of the invention, incorporating the biocidal oligomers, can be used to suppress bacterial growth in wound and surgical dressings and personal hygiene products.

Antimicrobial materials and methods

Thiophene containing water-soluble oligomers were synthesized and characterized. The photophysical properties of these compounds were studied; transient absorption spectroscopy was used to probe the triplet excited state and their ability to sensitize singlet oxygen was spectroscopically monitored in deuterated methanol. The above compounds were tested for their light activated biocidal properties againstboth under UV and visible radiation. Among the oligomers studied, the terthiophene derivative was found to kill the bacteria efficiently.

Thiophene based oligomers as light activated biocides

Growing community of inventors

Ervy le Chatel, France

Dimitri Dascier