Cornell University

Dimitre Gueorguiev Ouzounov

Watt W Webb

Chunhui (Chris) Xu

Frank Wise

Alexander Gaeta

Douglas Scherr

Scott Howard

Rebecca M Williams

Warren Zipfel

Shian Zhou

David R Rivera

Christopher M Brown

Demirhan Kobat

David Huland

A microendoscope, and a microendoscopy method related to the microendoscope, each include a tube housing, where an end of the tube housing is shaped and finished to facilitate collection of light emitted from a sample when examined using the microendoscope. In addition, a catadioptric lens assembly, an endomicroscope that includes the catadioptric lens assembly and a microendoscopy method for microscopic analysis that uses the endomicroscope are predicated upon a second element and a third element within the catadioptric lens assembly that each has a dichroic coating. The placement of the dichroic coating on the second element and the third element provides for different magnification factors as a function of illumination wavelength when using the microendoscopy method.

Dual mode microendoscope concentrating light emission into ring area

An optical scanner, scanner apparatus, or scanner assembly, which may be particularly advantageous for use in a multiphoton microscope, includes a first drivable bending component, a second drivable bending component mounted perpendicularly to the first component, and at least one optical waveguide coupled one or both of the first and second bending components, wherein the at least one optical waveguide provides both a propagation path for a multiphoton excitation radiation delivery between a light source and a target and a multiphoton-induced emission radiation delivery between the target and a detector. A GRIN relay lens. A multiphoton microscope incorporating the scanner and the GRIN relay lens.

Multi-path, multi-magnification, non-confocal fluorescence emission endoscopy apparatus and methods

To avoid harmful nonlinear effects in the amplification of short optical pulses, an initial pulse is divided into a sequence of lower-energy temporally spaced pulses that are otherwise identical to the original pulse. The low-intensity pulses are amplified and then recombined to create a final amplified output pulse.

Divided-pulse amplification of short pulses

The present invention is directed to a method of applying radiation through an optical fiber for detecting disease within a plant or animal or other penetrable tissue, or imaging a particular tissue of a plant or animal. In addition, fluorescence and nonlinear scattering signals can be detected and localized within a subject by such application of radiation through an optical fiber. The radiation is effective to promote simultaneous multiphoton excitation. The optical fibers are used alone to examine internal regions of tissue, in conjunction with an optical biopsy needle to evaluate sub-surface tissue, or with an endoscope to evaluate tissue within body cavities. The present invention also relates to a device for coupling in radiation from an ultrashort mode-locked laser into the beam path of a microscope.

Optical fiber delivery and collection method for biological applications such as multiphoton microscopy, spectroscopy, and endoscopy

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Ithaca, NY, United States of America

Dimitre Gueorguiev Ouzounov